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European Clinical Research Alliance on Infectious Diseases

Objective

ECRAID-Base (European Clinical Research Alliance for Infectious Diseases) continues the activities of PREPARE, COMBACTE and ECRAID-Plan, which will lead to establishing ECRAID as an independent non-for-profit legal entity in December 2020. ECRAID-Base is the initial set of activities for ECRAID.
As a European clinical research network ECRAID-Base will generate rigorous evidence to improve diagnosis, prevention and treatment of infections and to better respond to EID threats.. The network has already been successfully used during the COVID-19 pandemic, with valuable lessons learned.
At the heart of ECRAID-Base are 6 perpetual studies; 5 observational studies in ICU (WP2), ER (WP3,4&5) and primary care (WP6), addressing infections relevant for AMR (VAP in WP2 & cUTI in WP3) and EID (ARI in WP4 & WP6, and Disease X in WP5). All will mature towards adaptive platform trials, with capability to rapidly respond to public health threats. These 5 studies will enroll around 20,000 patients per year.
The sixth perpetual study is the Randomized Embedded Multifactorial Adaptive Platform (REMAP) for patients with severe CAP in ICU, with capability of rapid adaptation to new public health threats as demonstrated. In a response to COVID-19 the platform was (within 2 months) adapted with new COVID-19 treatment domains and enrolment of non-ICU patients, and the number active sites rapidly increased in 213 sites (June 4th) with 1084 patients enrolled (567 with COVID-19).
Supportive to the clinical studies are work packages LAB (for laboratory support), DATA (for datamanagement and innovative epidemiological and statistical research), TRAIN (for training) and PREP (for improving responsiveness to new public health threats).
ECRAID-Base, therefore, establishes a pan-European clinical research network to increase efficiency for testing and developing new diagnostic, preventive and/or therapeutic strategies and therapies and improving responsiveness to new public health thretbd

Field of science

  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention
  • /medical and health sciences/health sciences/infectious disease/RNA virus/coronavirus

Call for proposal

H2020-SC1-2020-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 6 909 040

Participants (17)

UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 3 385 000
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
EU contribution
€ 224 687,50
Address
5 Rue Watt
75013 Paris
Activity type
Research Organisations
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 4 314 228,75
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Centre hospitalier universitaire de Limoges
France
EU contribution
€ 2 501 250
Address
Avenue Martin-luther-king 2
87000 Limoges
Activity type
Research Organisations
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 2 846 842,50
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
FONDAZIONE PENTA - FOR THE TREATMENT AND CARE OF CHILDREN WITH HIV ANDRELATED DISEASES - ONLUS
Italy
EU contribution
€ 250 000
Address
Corso Stati Uniti 4
35127 Padova
Activity type
Research Organisations
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 1 674 450
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 1 600 023,75
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 291 526,25
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 2 652 500
Address
Avenida De La Constitucion 18
41071 Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 999 815
Address
Via Dell Artigliere 8
37129 Verona
Activity type
Higher or Secondary Education Establishments
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 100 000
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 200 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
INTENSIVE CARE NATIONAL AUDIT AND RESEARCH CENTRE
United Kingdom
EU contribution
€ 608 011,25
Address
Napier House 24 High Holborn
WC1V 6AZ London
Activity type
Research Organisations
KLINIKA ZA INFEKTIVNE BOLESTI DR. FRAN MIHALJEVIC
Croatia
EU contribution
€ 410 000
Address
Mirogojska Cesta 8
10000 Zagreb
Activity type
Research Organisations
EUROPEAN SOCIETY CLINICAL MICROBIOLOGY INFECTIOUS DISEASES (EUROPAISCHE GESELLSCHAFT FUR KLINISCHE MIKROBIOLOGIE INFEKTIONSKRANKHEITEN)
Switzerland
EU contribution
€ 502 500
Address
Gerbergasse 14
4001 Basel
Activity type
Other
EUROPEAN RESPIRATORY SOCIETY
Switzerland
EU contribution
€ 500 000
Address
Avenue Sainte Luce 4
1003 Lausanne
Activity type
Other