Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients

Información del proyecto

TIMESPAN

Identificador del acuerdo de subvención: 965381

DOI

10.3030/965381

Fecha de la firma de la CE 25 Enero 2021

Fecha de inicio 1 Abril 2021

Fecha de finalización 31 Marzo 2026

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 6 811 451,00

Aportación de la UE

€ 5 999 986,00

Coordinado por

OREBRO UNIVERSITY
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (5)

Report on Ethics Monitoring Strategy

D71 Report on Ethics Monitoring Strategy Month 3

Systematic review covering the available evidence on ADHD and cardiometabolic disease

Systematic review covering the available evidence on ADHD and cardiometabolic disease (Month 24)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (incl. evaluation of the independent ethics advisor) (Month 18)

1) EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation 2) Prevention of misuse of research participant’s data (data security measures to prevent unauthorized access and data breach, anonymization techniques, encryption, secure data transfer, controllerprocessor agreement ensuring high security standards (for the remote collection)). Such measures will mitigate the possible risks for the research participants 3) Ethical considerations in relation to AI applications (terms of fairness, discrimination, inequality, avoidance of harm, conflicts of autonomy, beneficence, non-maleficence, justice, the “black box” problem in AI, and accountability)4) The entire report will be evaluated by an independent ethics advisor

Communication and Outreach plan

Communication and Outreach plan Month 6

EDB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (Month 36)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (Month 36)

Other (2)

DLNN algorithms (freely available via GitHub) (Task 4)

D62 DLNN algorithms freely available via GitHub Task 4 Month 15

DLNN algorithms (freely available via GitHub) (Task 1)

D6.1: DLNN algorithms (freely available via GitHub) (Task 1) (Month 6)

Websites, patent fillings, videos etc. (5)

Training course in pharmaco-epidemiological analyses using real-world data for relevant stakeholders

Training course in pharmaco-epidemiological analyses using real-world data for relevant stakeholders (Month 48)

Project brochure and professional templates

Project brochure and professional templates Month 6

Patient and layman event

Patient and layman event (Month 50)

Go-online of the public project website (Month 04)

Goonline of the public project website Month 04

Go-online of the public project website

Goonline of the public project website Month 4

Publicaciones

Peer reviewed articles (34)

Predicting childhood and adolescent attention-deficit/hyperactivity disorder onset: a nationwide deep learning approach

Autores: Miguel Garcia-Argibay, Yanli Zhang-James, Samuele Cortese, Paul Lichtenstein, Henrik Larsson & Stephen V. Faraone
Publicado en: Molecular Psychiatry, Edición 28, 2022, Página(s) 1232–1239, ISSN 1476-5578
Editor: Springer Nature
DOI: 10.1038/s41380-022-01918-8

Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs

Autores: Adrienne Y. L. Chan, Le Gao, Miyuki Hsing-Chun Hsieh, Lars J. Kjerpeseth, Raquel Avelar, Tobias Banaschewski, Amy Hai Yan Chan, David Coghill, Jacqueline M. Cohen, Mika Gissler, Jeff Harrison, Patrick Ip, Øystein Karlstad, Wallis C. Y. Lau, Maarit K. Leinonen, Wing Cheong Leung, Tzu-Chi Liao, Johan Reutfors, Shih-Chieh Shao, Emily Simonoff, Kathryn Choon Beng Tan, Katja Taxis, Andrew Tomlin, Caro
Publicado en: Nature Medicine, Edición 30, 2024, Página(s) 1416-1423, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-024-02917-8

Cardiovascular risk factors in attention-deficit/hyperactivity disorder: A family design study of Swedish conscripts

Autores: Larsson H, Garcia-Argibay M, Du Rietz E, Hartman CA, Lichtenstein P, Chang Z, Fava C, Cortese S
Publicado en: International Journal of Methods in Psychiatric Research, Edición 10498931, 2022, ISSN 1049-8931
Editor: Whurr Publishers Ltd.
DOI: 10.1002/mpr.1930

Psychiatric comorbidities in women with cardiometabolic conditions with and without ADHD: a population-based study

Autores: Jakobsdottir Smari U, Valdimarsdottir UA Aspelund T, Hauksdottir A, Thordardottir EB, Hartman CA, Andell P, Henrik Larsson H, Zoega H
Publicado en: BMC Medicine, 2023, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-023-03160-7

Nonlinear associations between insomnia symptoms and circadian preferences in the general population: Symptom-specific and lifespan differences in men and women

Autores: Sarsembayeva, D., Hartman, C. A., Cardoso Melo, R. D., & Schreuder, M. J.
Publicado en: Sleep health, 2023, ISSN 2352-7218
Editor: Elsevier Inc.
DOI: 10.1016/j.sleh.2023.10.008

The role of ADHD genetic risk in mid-to-late life somatic health conditions

Autores: Brikell I, Garcia-Argibay M, du Rietz E, Lu Y, Martin J, Haan E, Lehto K, Bergen SE, Lichtenstein P, Larsson H
Publicado en: Translational Psychiatry, Edición 21583188, 2022, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-022-01933-x

Somatic burden of attention‐deficit/hyperactivity disorder across the lifecourse

Autores: Berit Libutzki, Benno Neukirch, Andreas Reif, Catharina A. Hartman
Publicado en: Acta Psychiatrica Scandinavica, Edición 150, 2025, Página(s) 105-117, ISSN 0001-690X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acps.13694

The contribution of attention-deficit/hyperactivity disorder polygenic load to metabolic and cardiovascular health outcomes: a large-scale population and sibling study

Autores: Ebba Du Rietz, Tian Xie, Rujia Wang, Rosa Cheesman, Miguel Garcia-Argibay, Zihan Dong, Jia Zhang, Jacobien Niebuur, Melissa Vos, Harold Snieder, Henrik Larsson, Catharina A. Hartman
Publicado en: Translational Psychiatry, Edición 14, 2024, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-024-03178-2

Association of ADHD symptoms with type 2 diabetes and cardiovascular comorbidities in adults receiving outpatient diabetes care.

Autores: A. Z. Dehnavi, Y. Zhang-James, D. Draytsel, B. Carguello, S.V. Faraone and R. S. Weinstock
Publicado en: Journal of Clinical & Translational Endocrinology, Edición 32, 2023, ISSN 2214-6237
Editor: Elsevier
DOI: 10.1016/j.jcte.2023.100318

Expanded access to publicly subsidised lisdexamfetamine treatment for adults with attention-deficit/hyperactivity disorder: An interrupted time-series analysis

Autores: Bruno C, Zoega H, Gillies MB, et al.
Publicado en: The Australian and New Zealand Journal of Psychiatry, Edición 57(7):1073-1076, 2023, ISSN 1440-1614
Editor: Australian and New Zealand journal of psychiatry
DOI: 10.1177/00048674231170556

Distal-to-proximal etiologically relevant variables associated with the general (p) and specific factors of psychopathology

Autores: Ormel, J., Vos, M., Laceulle, O. M., Vrijen, C., van der Laan, C. M., Nolte, I. M., & Hartman, C. A.
Publicado en: Journal of Child Psychology and Psychiatry, 2024, ISSN 1469-7610
Editor: Wiley-Blackwell
DOI: 10.1111/jcpp.13979

Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases

Autores: Le Zhang, Lin Li, Pontus Andell, Miguel Garcia-Argibay, Patrick D. Quinn, Brian M. D’Onofrio, Isabell Brikell, Ralf Kuja-Halkola, Paul Lichtenstein, Kristina Johnell, Henrik Larsson, Zheng Chang
Publicado en: JAMA psychiatry, 2022, ISSN 1538-3636
Editor: American Medical Association (USA)
DOI: 10.1001/jamapsychiatry.2023.4294

Attention-Deficit/Hyperactivity Disorder and Major Depressive Disorder: Evidence From Multiple Genetically Informed Designs

Autores: Garcia Argibay, M., Isabell Brikell, Anita Thapar, Paul Lichtenstein, Sebastian Lundström, Ditte Demontis, Henrik Larsson
Publicado en: Biological Psychiatry, Edición Volume 95, ISSUE 5, 2023, Página(s) P444-452, ISSN 1873-2402
Editor: Biological Psychiatry
DOI: 10.1016/j.biopsych.2023.07.017

The association between type 2 diabetes and attention- deficit/hyperactivity disorder: A systematic review, meta-analysis, and population-based sibling study

Autores: Miguel Garcia-Argibay, Lin Li, Ebba Du Rietz, Le Zhang, Honghui Yao, Johan Jendle, Josep A. Ramos-Quiroga, Marta Ribasés, Zheng Chang, Isabell Brikell, Samuele Cortese, Henrik Larsson
Publicado en: Neuroscience & Biobehavioral Reviews, Edición Volume 147, 105076, 2023, ISSN 0149-7634
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105076

Attention-deficit/hyperactivity disorder as a risk factor for cardiovascular diseases: a nationwide population-based cohort study

Autores: Larsson H, Li L, Chang Z, Sun J, Garcia-Argibay M, Du Rietz E, Dobrosavljevic M, Brikell I, Jernberg T, Solmi M, Cortese S
Publicado en: World Psychiatry, Edición 17238617, 2022, Página(s) 452-459, ISSN 1723-8617
Editor: Masson Italia Periodici
DOI: 10.1002/wps.21020

ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol

Autores: Denyer H, Ramos-Quiroga JA, Folarin A, Ramos C, Nemeth P, Bilbow A, Woodward E, Whitwell S, Müller-Sedgwick U, Larsson H, Dobson RJB, Kuntsi J.
Publicado en: BMC Psychiatry, Edición 22, 2022, Página(s) 813, ISSN 1471-244X
Editor: BioMed Central
DOI: 10.1186/s12888-022-04429-6

Methylphenidate and Short-Term Cardiovascular Risk

Autores: Miguel Garcia-Argibay, Paul-Christian Bürkner, Paul Lichtenstein, Le Zhang, Brian M. D’Onofrio, Pontus Andell, Zheng Chang, Samuele Cortese, Henrik Larsson
Publicado en: JAMA Network Open, Edición 2024;7(3):e241349, 2024, ISSN 2574-3805
Editor: Jama Network Open
DOI: 10.1001/jamanetworkopen.2024.1349

Association Between ADHD and COVID-19 Infection and Clinical Outcomes: A Retrospective Cohort Study From Electronic Medical Records

Autores: Kathaleen Heslin, Aminat Haruna, Regina A George, Shiyu Chen, Ishak Nobel, Kathryn B Anderson, Stephen V Faraone and Yanli Zhang-James
Publicado en: Journal of Attention Disorders, 2022, ISSN 1087-0547
Editor: SAGE Publications
DOI: 10.1177/10870547221129305

Risk of cardiovascular diseases associated with medications used in attention-deficit/hyperactivity disorder: A systematic review and meta-analysis

Autores: Zheng Chang, Le Zhang, Honghui Yao, Lin Li, Ebba Du Rietz, Pontus Andell, Miguel Garcia-Argibay, Brian M. D’Onofrio, Samuele Cortese, Henrik Larsson
Publicado en: JAMA Network Open / Psychiatry, 2022, ISSN 2168-622X
Editor: American Medical Association
DOI: 10.1001/jamanetworkopen.2022.43597

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

Autores: Zhou, H., Kember, R.L., Deak, J.D. et al.
Publicado en: Nature Medicine, Edición 29, 3184–3192, 2023, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-023-02653-5

Association between Attention Deficit Hyperactivity Disorder and outcomes after metabolic and bariatric surgery: a nationwide propensity matched cohort study

Autores: Erik Stenberg, Henrik Larsson, Richard Marsk, Yang Cao, Magnus Sundbom, Erik Näslund
Publicado en: Surgery for Obesity and Related Diseases, 2022, ISSN 1550-7289
Editor: Elsevier BV
DOI: 10.1016/j.soard.2022.10.028

Effects of ADHD and ADHD treatment on glycemic management in type 1 diabetes: A systematic review and meta-analysis of observational studies.

Autores: A. Zare Dehnavi, I. Elmitwalli, H. O. H. Alsharif, A. Shervin Razavi, T. A. Gumpel, A. Smith, R. S. Weinstock, S.V. Faraone, Y. Zhang-James
Publicado en: Diabetes Research and Clinical Practice, 2024, Página(s) 111566, ISSN 1872-8227
Editor: Diabetes research and clinical practice.
DOI: 10.1016/j.diabres.2024.111566

26. THE IMPACT OF GENETIC FACTORS ON STIMULANT MEDICATION TREATMENT IN ADHD

Autores: Janne Thirstrup, Jinjie Duan, Anders Børglum, Isabell Brikell, Ditte Demontis
Publicado en: European Neuropsychopharmacology, Edición 87, 2024, Página(s) 61-62, ISSN 0924-977X
Editor: Elsevier BV
DOI: 10.1016/j.euroneuro.2024.08.140

Risk prediction model for cardiovascular diseases in adults initiating pharmacological treatment for attention-deficit/hyperactivity disorder

Autores: Maja Dobrosavljevic; Seena Fazel; Ebba Du Rietz; Lin Li; Le Zhang; Zheng Chang; Tomas Jernberg; Stephen V Faraone; Johan Jendle; Qi Chen; Isabell Brikell; Henrik Larsson
Publicado en: Evid Based Ment Health, Edición 13620347, 2022, ISSN 1362-0347
Editor: BMJ Publishing Group
DOI: 10.1136/ebmental-2022-300492

Attention-deficit/hyperactivity disorder and cardiometabolic risk profile in patients with acute myocardial infarction: data from the SWEDEHEART registry

Autores: Honghui Yao, Isabell Brikell, Henrik Larsson, Lin Li, Ebba Du Rietz, Catharina A Hartman, Tomas Jernberg, Pontus Andell, Zheng Chang
Publicado en: European Journal of Preventive Cardiology, 2025, ISSN 2047-4873
Editor: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwaf151

How can we improve the management of individuals with attention deficit hyperactivity disorders and co-occurring cardiometabolic disease?

Autores: Henrik Larsson
Publicado en: Expert Review of Cardiovascular Therapy, 2023, Página(s) Pages 725-728, ISSN 1477-9072
Editor: Future Drugs Ltd.
DOI: 10.1080/14779072.2023.2279608

Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes.

Autores: Ribasés, M., Mitjans, M., Hartman, C. A., Soler Artigas, M., Demontis, D., Larsson, H., Ramos-Quiroga, J. A., Kuntsi, J., Faraone, S. V., Børglum, A. D., Reif, A., Franke, B., & Cormand, B.
Publicado en: Neuroscience and Biobehavioral Reviews, Edición 153, Article 105313, 2023, ISSN 1873-7528
Editor: Elsevier
DOI: 10.1016/j.neubiorev.2023.105313

Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: utilizing electronic health records in a Phenome-Wide Association Study.

Autores: Haan E, Krebs K, Võsa U, Brikell I, Larsson H, Lehto K.
Publicado en: Psychological Medicine., 2024, ISSN 1469-8978
Editor: Cambridge University Press
DOI: 10.1017/s0033291724000606

Cumulative ADHD medication use and risk of type 2 diabetes in adults: a Swedish Register study

Autores: Zihan Dong, Le Zhang, Lin Li, Shengxin Liu, Isabell Brikell, Ralf Kuja-Halkola, Brian M D’Onofrio, Agnieszka Butwicka, Soffia Gudbjornsdottir, Henrik Larsson, Zheng Chang, Ebba Du Rietz
Publicado en: BMJ Mental Health, Edición 27, 2025, Página(s) e301195, ISSN 2755-9734
Editor: BMJ
DOI: 10.1136/bmjment-2024-301195

Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study

Autores: J. Zhang, Z. K. Chen, R. D. Triatin, H. Snieder, C. H. L. Thio, C. A. Hartman
Publicado en: Epidemiology and Psychiatric Sciences, Edición 33, 2024, ISSN 2045-7960
Editor: Cambridge University Press
DOI: 10.1017/s2045796024000593

Rare coding variants in ten genes confer substantial risk for schizophrenia.

Autores: M.J. Daly, Singh, T., T. Poterba, D. Curtis, H. Akil, M. Al Eissa, J. D. Barchas, N. Bass, T. B. Bigdeli, G. Breen, E. J. Bromet, P. F. Buckley, W. E. Bunney, J. Bybjerg-Grauholm, W. F. Byerley, S. B. Chapman, W. J. Chen, C. Churchhouse, N. Craddock, C. M. Cusick, L. DeLisi, S. Dodge, M. A. Escamilla, S. Eskelinen, A. H. Fanous, S.V. Faraone, A. Fiorentino, L. Francioli, S. B. Gabriel, D. Gage, S.
Publicado en: Nature, Edición 00280836, 2022, Página(s) 509–516, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-04556-w

"Polygenic resilience scores capture protective genetic effects for Alzheimer's disease."""

Autores: Hou, J., J. L. Hess, N. Armstrong, J. C. Bis, B. Grenier-Boley, I. K. Karlsson, G. Leonenko, K. Numbers, E. K. O'Brien, A. Shadrin, A. Thalamuthu, Q. Yang, O. A. Andreassen, H. Brodaty, M. Gatz, N. A. Kochan, J. C. Lambert, S. M. Laws, C. L. Masters, K. A. Mather, N. L. Pedersen, D. Posthuma, P. S. Sachdev, J. Williams, C. C. Fan, S. V. Faraone, C. Fennema-Notestine, S. J. Lin, V. Escott-Price, P.
Publicado en: Transl Psychiatry, Edición 21583188, 2022, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-022-02055-0

Attention-deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta-analysis

Autores: Lin Li, Honghui Yao, Le Zhang, Miguel Garcia-Argibay, Ebba Du Rietz, Isabell Brikell, Marco Solmi, Samuele Cortese, J. Antoni Ramos-Quiroga, Marta Ribasés, Zheng Chang, Henrik Larsson
Publicado en: JCPP Advances, 2023, ISSN 2692-9384
Editor: JCPP advances
DOI: 10.1002/jcv2.12158

Patterns of attention deficit hyperactivity disorder medicine use in the era of new non-stimulant medicines: A population-based study among Australian children and adults (2013–2020)

Autores: Bruno C, Alys Havard, Malcolm B Gillies, David Coghill, Jonathan Brett, Adam J Guastella, Sallie-Anne Pearson, Helga Zoega
Publicado en: Australia N Z J Psychiatry, 2022, ISSN 0004-8674
Editor: Blackwell Publishing Inc.
DOI: 10.1177/00048674221114782

Other (3)

Attention-deficit/hyperactivity disorder medication use and cardiometabolic conditions in pregnancy: A population-based cohort study

Autores: Andrea Sit, Claudia Bruno, Masako Araki, Malcolm Gillies, Helga Zoega
Publicado en: 2024
Editor: Authorea, Inc.
DOI: 10.22541/au.172742419.94824081/v1

Using Genomic Context Informed Genotype Data and Within‐model Ancestry Adjustment to Classify Type 2 Diabetes

Autores: Eric J Barnett, Yanli Zhang-James, Jonathan Hess, Stephen J Glatt, Stephen V Faraone
Publicado en: 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.12.24313579

Adhd Symptoms are Common and Associated with Worse Glycemic Control in Adults with Type 1 Diabetes

Autores: Yanli Zhang-James, Dan Draytsel, Ben Carguello, Stephen V. Faraone, Ruth S. Weinstock
Publicado en: Journal of Clinical Medicine (in revision; preprint is published on SSRN), 2024
Editor: Elsevier BV
DOI: 10.2139/ssrn.4856029

Thesis and dissertations (2)

Using real-world data to generate evidence to improve quality use of psychotropic medicines in priority populations.

Autores: Bruno, Claudia
Publicado en: 2023
Editor: University of New South Wales
DOI: 10.26190/unsworks/25402

Cardiovascular medicine use in adults with ADHD: A nationwide study in Australia

Autores: Masako Araki
Publicado en: 2023
Editor: Research Gate

Conference proceedings (1)

ABSTRACTS of the 2024 ISPE Annual Meeting, Berlin, Germany, 24–28 August 2024

Autores: Araki M., Zoega H., Gillies M.B., Falster M., Peirs D., Larsson H., Costa J.
Publicado en: Pharmacoepidemiology and Drug Safety, Edición 33, 2024, ISSN 1053-8569
Editor: John Wiley & Sons Inc.
DOI: 10.1002/pds.5891