Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients

Informations projet

TIMESPAN

N° de convention de subvention: 965381

DOI

10.3030/965381

Date de signature de la CE 25 Janvier 2021

Date de début 1 Avril 2021

Date de fin 31 Mars 2026

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 6 811 451,00

Contribution de l’UE

€ 5 999 986,00

Coordonné par

OREBRO UNIVERSITY
Sweden

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (5)

Report on Ethics Monitoring Strategy

D71 Report on Ethics Monitoring Strategy Month 3

Systematic review covering the available evidence on ADHD and cardiometabolic disease

Systematic review covering the available evidence on ADHD and cardiometabolic disease (Month 24)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (incl. evaluation of the independent ethics advisor) (Month 18)

1) EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation 2) Prevention of misuse of research participant’s data (data security measures to prevent unauthorized access and data breach, anonymization techniques, encryption, secure data transfer, controllerprocessor agreement ensuring high security standards (for the remote collection)). Such measures will mitigate the possible risks for the research participants 3) Ethical considerations in relation to AI applications (terms of fairness, discrimination, inequality, avoidance of harm, conflicts of autonomy, beneficence, non-maleficence, justice, the “black box” problem in AI, and accountability)4) The entire report will be evaluated by an independent ethics advisor

Communication and Outreach plan

Communication and Outreach plan Month 6

EDB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (Month 36)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (Month 36)

Other (2)

DLNN algorithms (freely available via GitHub) (Task 4)

D62 DLNN algorithms freely available via GitHub Task 4 Month 15

DLNN algorithms (freely available via GitHub) (Task 1)

D6.1: DLNN algorithms (freely available via GitHub) (Task 1) (Month 6)

Websites, patent fillings, videos etc. (5)

Training course in pharmaco-epidemiological analyses using real-world data for relevant stakeholders

Training course in pharmaco-epidemiological analyses using real-world data for relevant stakeholders (Month 48)

Project brochure and professional templates

Project brochure and professional templates Month 6

Patient and layman event

Patient and layman event (Month 50)

Go-online of the public project website (Month 04)

Goonline of the public project website Month 04

Go-online of the public project website

Goonline of the public project website Month 4

Publications

Peer reviewed articles (34)

Predicting childhood and adolescent attention-deficit/hyperactivity disorder onset: a nationwide deep learning approach

Auteurs: Miguel Garcia-Argibay, Yanli Zhang-James, Samuele Cortese, Paul Lichtenstein, Henrik Larsson & Stephen V. Faraone
Publié dans: Molecular Psychiatry, Numéro 28, 2022, Page(s) 1232–1239, ISSN 1476-5578
Éditeur: Springer Nature
DOI: 10.1038/s41380-022-01918-8

Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs

Auteurs: Adrienne Y. L. Chan, Le Gao, Miyuki Hsing-Chun Hsieh, Lars J. Kjerpeseth, Raquel Avelar, Tobias Banaschewski, Amy Hai Yan Chan, David Coghill, Jacqueline M. Cohen, Mika Gissler, Jeff Harrison, Patrick Ip, Øystein Karlstad, Wallis C. Y. Lau, Maarit K. Leinonen, Wing Cheong Leung, Tzu-Chi Liao, Johan Reutfors, Shih-Chieh Shao, Emily Simonoff, Kathryn Choon Beng Tan, Katja Taxis, Andrew Tomlin, Caro
Publié dans: Nature Medicine, Numéro 30, 2024, Page(s) 1416-1423, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-024-02917-8

Cardiovascular risk factors in attention-deficit/hyperactivity disorder: A family design study of Swedish conscripts

Auteurs: Larsson H, Garcia-Argibay M, Du Rietz E, Hartman CA, Lichtenstein P, Chang Z, Fava C, Cortese S
Publié dans: International Journal of Methods in Psychiatric Research, Numéro 10498931, 2022, ISSN 1049-8931
Éditeur: Whurr Publishers Ltd.
DOI: 10.1002/mpr.1930

Psychiatric comorbidities in women with cardiometabolic conditions with and without ADHD: a population-based study

Auteurs: Jakobsdottir Smari U, Valdimarsdottir UA Aspelund T, Hauksdottir A, Thordardottir EB, Hartman CA, Andell P, Henrik Larsson H, Zoega H
Publié dans: BMC Medicine, 2023, ISSN 1741-7015
Éditeur: BioMed Central
DOI: 10.1186/s12916-023-03160-7

Nonlinear associations between insomnia symptoms and circadian preferences in the general population: Symptom-specific and lifespan differences in men and women

Auteurs: Sarsembayeva, D., Hartman, C. A., Cardoso Melo, R. D., & Schreuder, M. J.
Publié dans: Sleep health, 2023, ISSN 2352-7218
Éditeur: Elsevier Inc.
DOI: 10.1016/j.sleh.2023.10.008

The role of ADHD genetic risk in mid-to-late life somatic health conditions

Auteurs: Brikell I, Garcia-Argibay M, du Rietz E, Lu Y, Martin J, Haan E, Lehto K, Bergen SE, Lichtenstein P, Larsson H
Publié dans: Translational Psychiatry, Numéro 21583188, 2022, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-022-01933-x

Somatic burden of attention‐deficit/hyperactivity disorder across the lifecourse

Auteurs: Berit Libutzki, Benno Neukirch, Andreas Reif, Catharina A. Hartman
Publié dans: Acta Psychiatrica Scandinavica, Numéro 150, 2025, Page(s) 105-117, ISSN 0001-690X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/acps.13694

The contribution of attention-deficit/hyperactivity disorder polygenic load to metabolic and cardiovascular health outcomes: a large-scale population and sibling study

Auteurs: Ebba Du Rietz, Tian Xie, Rujia Wang, Rosa Cheesman, Miguel Garcia-Argibay, Zihan Dong, Jia Zhang, Jacobien Niebuur, Melissa Vos, Harold Snieder, Henrik Larsson, Catharina A. Hartman
Publié dans: Translational Psychiatry, Numéro 14, 2024, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-024-03178-2

Association of ADHD symptoms with type 2 diabetes and cardiovascular comorbidities in adults receiving outpatient diabetes care.

Auteurs: A. Z. Dehnavi, Y. Zhang-James, D. Draytsel, B. Carguello, S.V. Faraone and R. S. Weinstock
Publié dans: Journal of Clinical & Translational Endocrinology, Numéro 32, 2023, ISSN 2214-6237
Éditeur: Elsevier
DOI: 10.1016/j.jcte.2023.100318

Expanded access to publicly subsidised lisdexamfetamine treatment for adults with attention-deficit/hyperactivity disorder: An interrupted time-series analysis

Auteurs: Bruno C, Zoega H, Gillies MB, et al.
Publié dans: The Australian and New Zealand Journal of Psychiatry, Numéro 57(7):1073-1076, 2023, ISSN 1440-1614
Éditeur: Australian and New Zealand journal of psychiatry
DOI: 10.1177/00048674231170556

Distal-to-proximal etiologically relevant variables associated with the general (p) and specific factors of psychopathology

Auteurs: Ormel, J., Vos, M., Laceulle, O. M., Vrijen, C., van der Laan, C. M., Nolte, I. M., & Hartman, C. A.
Publié dans: Journal of Child Psychology and Psychiatry, 2024, ISSN 1469-7610
Éditeur: Wiley-Blackwell
DOI: 10.1111/jcpp.13979

Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases

Auteurs: Le Zhang, Lin Li, Pontus Andell, Miguel Garcia-Argibay, Patrick D. Quinn, Brian M. D’Onofrio, Isabell Brikell, Ralf Kuja-Halkola, Paul Lichtenstein, Kristina Johnell, Henrik Larsson, Zheng Chang
Publié dans: JAMA psychiatry, 2022, ISSN 1538-3636
Éditeur: American Medical Association (USA)
DOI: 10.1001/jamapsychiatry.2023.4294

Attention-Deficit/Hyperactivity Disorder and Major Depressive Disorder: Evidence From Multiple Genetically Informed Designs

Auteurs: Garcia Argibay, M., Isabell Brikell, Anita Thapar, Paul Lichtenstein, Sebastian Lundström, Ditte Demontis, Henrik Larsson
Publié dans: Biological Psychiatry, Numéro Volume 95, ISSUE 5, 2023, Page(s) P444-452, ISSN 1873-2402
Éditeur: Biological Psychiatry
DOI: 10.1016/j.biopsych.2023.07.017

The association between type 2 diabetes and attention- deficit/hyperactivity disorder: A systematic review, meta-analysis, and population-based sibling study

Auteurs: Miguel Garcia-Argibay, Lin Li, Ebba Du Rietz, Le Zhang, Honghui Yao, Johan Jendle, Josep A. Ramos-Quiroga, Marta Ribasés, Zheng Chang, Isabell Brikell, Samuele Cortese, Henrik Larsson
Publié dans: Neuroscience & Biobehavioral Reviews, Numéro Volume 147, 105076, 2023, ISSN 0149-7634
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105076

Attention-deficit/hyperactivity disorder as a risk factor for cardiovascular diseases: a nationwide population-based cohort study

Auteurs: Larsson H, Li L, Chang Z, Sun J, Garcia-Argibay M, Du Rietz E, Dobrosavljevic M, Brikell I, Jernberg T, Solmi M, Cortese S
Publié dans: World Psychiatry, Numéro 17238617, 2022, Page(s) 452-459, ISSN 1723-8617
Éditeur: Masson Italia Periodici
DOI: 10.1002/wps.21020

ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol

Auteurs: Denyer H, Ramos-Quiroga JA, Folarin A, Ramos C, Nemeth P, Bilbow A, Woodward E, Whitwell S, Müller-Sedgwick U, Larsson H, Dobson RJB, Kuntsi J.
Publié dans: BMC Psychiatry, Numéro 22, 2022, Page(s) 813, ISSN 1471-244X
Éditeur: BioMed Central
DOI: 10.1186/s12888-022-04429-6

Methylphenidate and Short-Term Cardiovascular Risk

Auteurs: Miguel Garcia-Argibay, Paul-Christian Bürkner, Paul Lichtenstein, Le Zhang, Brian M. D’Onofrio, Pontus Andell, Zheng Chang, Samuele Cortese, Henrik Larsson
Publié dans: JAMA Network Open, Numéro 2024;7(3):e241349, 2024, ISSN 2574-3805
Éditeur: Jama Network Open
DOI: 10.1001/jamanetworkopen.2024.1349

Association Between ADHD and COVID-19 Infection and Clinical Outcomes: A Retrospective Cohort Study From Electronic Medical Records

Auteurs: Kathaleen Heslin, Aminat Haruna, Regina A George, Shiyu Chen, Ishak Nobel, Kathryn B Anderson, Stephen V Faraone and Yanli Zhang-James
Publié dans: Journal of Attention Disorders, 2022, ISSN 1087-0547
Éditeur: SAGE Publications
DOI: 10.1177/10870547221129305

Risk of cardiovascular diseases associated with medications used in attention-deficit/hyperactivity disorder: A systematic review and meta-analysis

Auteurs: Zheng Chang, Le Zhang, Honghui Yao, Lin Li, Ebba Du Rietz, Pontus Andell, Miguel Garcia-Argibay, Brian M. D’Onofrio, Samuele Cortese, Henrik Larsson
Publié dans: JAMA Network Open / Psychiatry, 2022, ISSN 2168-622X
Éditeur: American Medical Association
DOI: 10.1001/jamanetworkopen.2022.43597

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

Auteurs: Zhou, H., Kember, R.L., Deak, J.D. et al.
Publié dans: Nature Medicine, Numéro 29, 3184–3192, 2023, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-023-02653-5

Association between Attention Deficit Hyperactivity Disorder and outcomes after metabolic and bariatric surgery: a nationwide propensity matched cohort study

Auteurs: Erik Stenberg, Henrik Larsson, Richard Marsk, Yang Cao, Magnus Sundbom, Erik Näslund
Publié dans: Surgery for Obesity and Related Diseases, 2022, ISSN 1550-7289
Éditeur: Elsevier BV
DOI: 10.1016/j.soard.2022.10.028

Effects of ADHD and ADHD treatment on glycemic management in type 1 diabetes: A systematic review and meta-analysis of observational studies.

Auteurs: A. Zare Dehnavi, I. Elmitwalli, H. O. H. Alsharif, A. Shervin Razavi, T. A. Gumpel, A. Smith, R. S. Weinstock, S.V. Faraone, Y. Zhang-James
Publié dans: Diabetes Research and Clinical Practice, 2024, Page(s) 111566, ISSN 1872-8227
Éditeur: Diabetes research and clinical practice.
DOI: 10.1016/j.diabres.2024.111566

26. THE IMPACT OF GENETIC FACTORS ON STIMULANT MEDICATION TREATMENT IN ADHD

Auteurs: Janne Thirstrup, Jinjie Duan, Anders Børglum, Isabell Brikell, Ditte Demontis
Publié dans: European Neuropsychopharmacology, Numéro 87, 2024, Page(s) 61-62, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/j.euroneuro.2024.08.140

Risk prediction model for cardiovascular diseases in adults initiating pharmacological treatment for attention-deficit/hyperactivity disorder

Auteurs: Maja Dobrosavljevic; Seena Fazel; Ebba Du Rietz; Lin Li; Le Zhang; Zheng Chang; Tomas Jernberg; Stephen V Faraone; Johan Jendle; Qi Chen; Isabell Brikell; Henrik Larsson
Publié dans: Evid Based Ment Health, Numéro 13620347, 2022, ISSN 1362-0347
Éditeur: BMJ Publishing Group
DOI: 10.1136/ebmental-2022-300492

Attention-deficit/hyperactivity disorder and cardiometabolic risk profile in patients with acute myocardial infarction: data from the SWEDEHEART registry

Auteurs: Honghui Yao, Isabell Brikell, Henrik Larsson, Lin Li, Ebba Du Rietz, Catharina A Hartman, Tomas Jernberg, Pontus Andell, Zheng Chang
Publié dans: European Journal of Preventive Cardiology, 2025, ISSN 2047-4873
Éditeur: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwaf151

How can we improve the management of individuals with attention deficit hyperactivity disorders and co-occurring cardiometabolic disease?

Auteurs: Henrik Larsson
Publié dans: Expert Review of Cardiovascular Therapy, 2023, Page(s) Pages 725-728, ISSN 1477-9072
Éditeur: Future Drugs Ltd.
DOI: 10.1080/14779072.2023.2279608

Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes.

Auteurs: Ribasés, M., Mitjans, M., Hartman, C. A., Soler Artigas, M., Demontis, D., Larsson, H., Ramos-Quiroga, J. A., Kuntsi, J., Faraone, S. V., Børglum, A. D., Reif, A., Franke, B., & Cormand, B.
Publié dans: Neuroscience and Biobehavioral Reviews, Numéro 153, Article 105313, 2023, ISSN 1873-7528
Éditeur: Elsevier
DOI: 10.1016/j.neubiorev.2023.105313

Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: utilizing electronic health records in a Phenome-Wide Association Study.

Auteurs: Haan E, Krebs K, Võsa U, Brikell I, Larsson H, Lehto K.
Publié dans: Psychological Medicine., 2024, ISSN 1469-8978
Éditeur: Cambridge University Press
DOI: 10.1017/s0033291724000606

Cumulative ADHD medication use and risk of type 2 diabetes in adults: a Swedish Register study

Auteurs: Zihan Dong, Le Zhang, Lin Li, Shengxin Liu, Isabell Brikell, Ralf Kuja-Halkola, Brian M D’Onofrio, Agnieszka Butwicka, Soffia Gudbjornsdottir, Henrik Larsson, Zheng Chang, Ebba Du Rietz
Publié dans: BMJ Mental Health, Numéro 27, 2025, Page(s) e301195, ISSN 2755-9734
Éditeur: BMJ
DOI: 10.1136/bmjment-2024-301195

Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study

Auteurs: J. Zhang, Z. K. Chen, R. D. Triatin, H. Snieder, C. H. L. Thio, C. A. Hartman
Publié dans: Epidemiology and Psychiatric Sciences, Numéro 33, 2024, ISSN 2045-7960
Éditeur: Cambridge University Press
DOI: 10.1017/s2045796024000593

Rare coding variants in ten genes confer substantial risk for schizophrenia.

Auteurs: M.J. Daly, Singh, T., T. Poterba, D. Curtis, H. Akil, M. Al Eissa, J. D. Barchas, N. Bass, T. B. Bigdeli, G. Breen, E. J. Bromet, P. F. Buckley, W. E. Bunney, J. Bybjerg-Grauholm, W. F. Byerley, S. B. Chapman, W. J. Chen, C. Churchhouse, N. Craddock, C. M. Cusick, L. DeLisi, S. Dodge, M. A. Escamilla, S. Eskelinen, A. H. Fanous, S.V. Faraone, A. Fiorentino, L. Francioli, S. B. Gabriel, D. Gage, S.
Publié dans: Nature, Numéro 00280836, 2022, Page(s) 509–516, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-04556-w

"Polygenic resilience scores capture protective genetic effects for Alzheimer's disease."""

Auteurs: Hou, J., J. L. Hess, N. Armstrong, J. C. Bis, B. Grenier-Boley, I. K. Karlsson, G. Leonenko, K. Numbers, E. K. O'Brien, A. Shadrin, A. Thalamuthu, Q. Yang, O. A. Andreassen, H. Brodaty, M. Gatz, N. A. Kochan, J. C. Lambert, S. M. Laws, C. L. Masters, K. A. Mather, N. L. Pedersen, D. Posthuma, P. S. Sachdev, J. Williams, C. C. Fan, S. V. Faraone, C. Fennema-Notestine, S. J. Lin, V. Escott-Price, P.
Publié dans: Transl Psychiatry, Numéro 21583188, 2022, ISSN 2158-3188
Éditeur: Nature Publishing Group
DOI: 10.1038/s41398-022-02055-0

Attention-deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta-analysis

Auteurs: Lin Li, Honghui Yao, Le Zhang, Miguel Garcia-Argibay, Ebba Du Rietz, Isabell Brikell, Marco Solmi, Samuele Cortese, J. Antoni Ramos-Quiroga, Marta Ribasés, Zheng Chang, Henrik Larsson
Publié dans: JCPP Advances, 2023, ISSN 2692-9384
Éditeur: JCPP advances
DOI: 10.1002/jcv2.12158

Patterns of attention deficit hyperactivity disorder medicine use in the era of new non-stimulant medicines: A population-based study among Australian children and adults (2013–2020)

Auteurs: Bruno C, Alys Havard, Malcolm B Gillies, David Coghill, Jonathan Brett, Adam J Guastella, Sallie-Anne Pearson, Helga Zoega
Publié dans: Australia N Z J Psychiatry, 2022, ISSN 0004-8674
Éditeur: Blackwell Publishing Inc.
DOI: 10.1177/00048674221114782

Other (3)

Attention-deficit/hyperactivity disorder medication use and cardiometabolic conditions in pregnancy: A population-based cohort study

Auteurs: Andrea Sit, Claudia Bruno, Masako Araki, Malcolm Gillies, Helga Zoega
Publié dans: 2024
Éditeur: Authorea, Inc.
DOI: 10.22541/au.172742419.94824081/v1

Using Genomic Context Informed Genotype Data and Within‐model Ancestry Adjustment to Classify Type 2 Diabetes

Auteurs: Eric J Barnett, Yanli Zhang-James, Jonathan Hess, Stephen J Glatt, Stephen V Faraone
Publié dans: 2024
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.12.24313579

Adhd Symptoms are Common and Associated with Worse Glycemic Control in Adults with Type 1 Diabetes

Auteurs: Yanli Zhang-James, Dan Draytsel, Ben Carguello, Stephen V. Faraone, Ruth S. Weinstock
Publié dans: Journal of Clinical Medicine (in revision; preprint is published on SSRN), 2024
Éditeur: Elsevier BV
DOI: 10.2139/ssrn.4856029

Thesis and dissertations (2)

Using real-world data to generate evidence to improve quality use of psychotropic medicines in priority populations.

Auteurs: Bruno, Claudia
Publié dans: 2023
Éditeur: University of New South Wales
DOI: 10.26190/unsworks/25402

Cardiovascular medicine use in adults with ADHD: A nationwide study in Australia

Auteurs: Masako Araki
Publié dans: 2023
Éditeur: Research Gate

Conference proceedings (1)

ABSTRACTS of the 2024 ISPE Annual Meeting, Berlin, Germany, 24–28 August 2024

Auteurs: Araki M., Zoega H., Gillies M.B., Falster M., Peirs D., Larsson H., Costa J.
Publié dans: Pharmacoepidemiology and Drug Safety, Numéro 33, 2024, ISSN 1053-8569
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/pds.5891