Skip to main content

3D Autonomous 2-PhoTon Optogenetics MICroscopy

Objective

Brain activity relies on complex interactions among large populations of neurons located in different brain regions. Understanding the relationships between these specific areas and disentangling the contributions of individual neurons to circuit function is an essential step to understand brain functioning. To elucidate the connection between brain activation and behaviour outcome, it is necessary to establish specific experimental strategies that allow to record and externally control neuronal activity during behaviour. Currently, there is an experimental trade-off between imaging speed, field of view and sample dimensions that limits current recording technology in imaging very large neuronal populations with concurrently high spatial and temporal resolution. Consequently, interactions between neurons in different brain areas are easily missed, whilst functionally related ensembles of neurons can be undetectable, blinded or falsely interpreted. DAPTOMIC aims to demonstrate the commercial viability of a new generation of autonomous (i.e. self-run, similar to a Tesla car) microscope add-on suitable for brain imaging. The main objective of DAPTOMIC is to turn the modules developed within the ERC Advanced Grant BrainBIT into a commercial product (minimum viable product), i.e. a new add-on to current generation microscopes that decides the imaging strategy - which portion of the sample to image and which portion of the sample to interact with – through AI, shortening experiment times by several orders of magnitude.

Call for proposal

ERC-2020-PoC
See other projects for this call

Funding Scheme

ERC-POC-LS - ERC Proof of Concept Lump Sum Pilot

Host institution

UNIVERSITA DEGLI STUDI DI FIRENZE
Address
Piazza San Marco 4
50121 Florence
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 150 000

Beneficiaries (1)

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 150 000
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments