Novel small molecule activators of the NLRP3 inflammasome as immunostimulants

Información del proyecto

IMMUNOSTIM

Identificador del acuerdo de subvención: 966687

DOI 10.3030/966687

Proyecto cerrado

Fecha de la firma de la CE 26 Agosto 2021

Fecha de inicio 1 Septiembre 2021

Fecha de finalización 28 Febrero 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 0,00

Aportación de la UE € 150 000,00

Coordinado por

UNIVERSITAETSKLINIKUM FREIBURG
Germany

Objetivo

We have identified a novel family of potent small molecule activators of the NLRP3 inflammasome. The goal of this project is to determine the feasibility of developing these new immunostimulators into an attractive commercial proposition. Establishment of technical feasibility will involve identification the most promising modifications of our drug candidates and testing their efficacy in disease models of cancer and immunization. In addition, we will determine commercial feasibility by conducting market research and competition analysis and by engaging potential industry partners.

Ámbito científico

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › basic medicine › immunology › immunisation
• medical and health sciences › clinical medicine › oncology

Palabras clave

• Immunostimulator
• Cancer-immune-escape
• Adjuvant
• Small-molecule drug
• Inflammasome
• NLRP3
• Interleukin-1

Programa(s)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Tema(s)

• ERC-2020-POC - Call for proposals for ERC Proof of Concept Grant

Convocatoria de propuestas

ERC-2020-PoC

Régimen de financiación

ERC-POC - Proof of Concept Grant

Institución de acogida

UNIVERSITAETSKLINIKUM FREIBURG

• Aportación neta de la UEn: € 150 000,00
• Dirección: HUGSTETTER STRASSE 49 ; 79106 Freiburg ; Alemania
• Región: Baden-Württemberg › Freiburg › Freiburg im Breisgau, Stadtkreis
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: Sin datos

Beneficiarios (1)

UNIVERSITAETSKLINIKUM FREIBURG

Alemania

• Aportación neta de la UEn: € 150 000,00
• Dirección: HUGSTETTER STRASSE 49 ; 79106 Freiburg
• Región: Baden-Württemberg › Freiburg › Freiburg im Breisgau, Stadtkreis
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: Sin datos