Novel small molecule activators of the NLRP3 inflammasome as immunostimulants

Informazioni relative al progetto

IMMUNOSTIM

ID dell’accordo di sovvenzione: 966687

DOI 10.3030/966687

Progetto chiuso

Data della firma CE 26 Agosto 2021

Data di avvio 1 Settembre 2021

Data di completamento 28 Febbraio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 0,00

Contributo UE € 150 000,00

Coordinato da

UNIVERSITAETSKLINIKUM FREIBURG
Germany

Obiettivo

We have identified a novel family of potent small molecule activators of the NLRP3 inflammasome. The goal of this project is to determine the feasibility of developing these new immunostimulators into an attractive commercial proposition. Establishment of technical feasibility will involve identification the most promising modifications of our drug candidates and testing their efficacy in disease models of cancer and immunization. In addition, we will determine commercial feasibility by conducting market research and competition analysis and by engaging potential industry partners.

Campo scientifico

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › basic medicine › immunology › immunisation
• medical and health sciences › clinical medicine › oncology

Parole chiave

• Immunostimulator
• Cancer-immune-escape
• Adjuvant
• Small-molecule drug
• Inflammasome
• NLRP3
• Interleukin-1

Programma(i)

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Argomento(i)

• ERC-2020-POC - Call for proposals for ERC Proof of Concept Grant

Invito a presentare proposte

ERC-2020-PoC

Meccanismo di finanziamento

ERC-POC - Proof of Concept Grant

Istituzione ospitante

UNIVERSITAETSKLINIKUM FREIBURG

• Contribution nette de l'UE: € 150 000,00
• Indirizzo: HUGSTETTER STRASSE 49 ; 79106 Freiburg ; Germania
• Regione: Baden-Württemberg › Freiburg › Freiburg im Breisgau, Stadtkreis
• Tipo di attività: Higher or Secondary Education Establishments
• Costo totale: Nessun dato

Beneficiari (1)

UNIVERSITAETSKLINIKUM FREIBURG

Germania

• Contribution nette de l'UE: € 150 000,00
• Indirizzo: HUGSTETTER STRASSE 49 ; 79106 Freiburg
• Regione: Baden-Württemberg › Freiburg › Freiburg im Breisgau, Stadtkreis
• Tipo di attività: Higher or Secondary Education Establishments
• Costo totale: Nessun dato