Project description
Predicting and treating bone marrow fibrosis
The bone marrow is the soft tissue inside most bones where continuous production of blood cells takes place. In rare cases, these cells are replaced by scar tissue, leading to fibrosis and gradual inability to produce blood cells. At present, there are no biomarkers to predict this transition and no anti-fibrotic therapies. The EU-funded de-ALARMIN project is building upon the work of a previous ERC-funded project on a specific molecule of the innate immune system. This molecule can serve as a prognostic biomarker of bone marrow fibrosis, while its therapeutic targeting ameliorates symptoms and even reduces the associated blood cancer cell burden.
Objective
The objective of this ERC Proof of Concept is to demonstrate the clinical application and commercial viability of a specific driver of the innate immune system as a novel predictive biomarker and as a novel therapeutic target for the diagnosis and treatment of bone marrow fibrosis related to blood cancer. This proposed project builds upon recent findings of my deFiber ERC Starting Grant (Stg) project, where we identified this danger-associated molecular pattern complex as exactly as such a prognostic and predictive biomarker and importantly showed that targeting with a small molecular, oral, anti-cancer inhibitor reduced fibrosis but also the cancer cell burden, in the sense of a targetable biomarker.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesclinical medicineoncology
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Programme(s)
Funding Scheme
ERC-POC - Proof of Concept GrantHost institution
3015 GD Rotterdam
Netherlands