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Novel Prognostic Personalized Biomarker and Therapeutic Target in Blood Cancer Related Fibrosis

Project description

Predicting and treating bone marrow fibrosis

The bone marrow is the soft tissue inside most bones where continuous production of blood cells takes place. In rare cases, these cells are replaced by scar tissue, leading to fibrosis and gradual inability to produce blood cells. At present, there are no biomarkers to predict this transition and no anti-fibrotic therapies. The EU-funded de-ALARMIN project is building upon the work of a previous ERC-funded project on a specific molecule of the innate immune system. This molecule can serve as a prognostic biomarker of bone marrow fibrosis, while its therapeutic targeting ameliorates symptoms and even reduces the associated blood cancer cell burden.

Host institution

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Net EU contribution
€ 150 000,00
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Beneficiaries (1)

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 150 000,00
Address
Dr Molewaterplein 40
3015 GD Rotterdam

See on map

Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Other funding
No data