The MILORD project concerns the storage, communication, and processing of large quantities of multimedia clinical information in an integrated environment. Advanced information technologies are exploited: new knowledge representation languages and tools, friendly human-computer interaction, 3-dimensional graphical processing and displaying of medical images, high performance parallel architecture, large-scale distributed data storage, federated environments for clinical co-operation. A medical application development system was designed and several applications were implemented taking account of physicians' requirements. During the MILORD project course, a strong research and development effort, linked with the continuous monitoring and assessment in the partner's clinical site, was devoted to the creation of a concrete base for future commercial systems. MILORD offers an environment through which the medical staff can manage directly all the information involved in the department as well as access the information provided by external sources.