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DEVELOPMENT OF METABOLICALLY COMPETENT IN VITRO MODELS FOR FOOD SAFETY EVALUATION

Objective



The overall objective is to develop in vitro assays using immortalised human cell lines for increased food safety. Specifically this will be achieved by fulfilling the following objectives:

- developing immortalised cell lines from human target organs and characterising their metabolic competence in comparison with normal tissues - correcting metabolic deficiencies in the developed cell lines by genetic manipulation
- establishing assays for cytoxicity, genotoxicity and malignant transformation using the developed cell lines.

Completion of this project will allow more rapid prediction of target organ-specific harmful or beneficial effects of food, including contaminants and additives. It will contribute to reduction, refinement and eventual replacement of animal tests.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Unilever UK Central Resources Ltd
Address
Colworth House
MK44 1LQ Sharnbrook
United Kingdom

Participants (14)

DANISH MEAT RESEARCH INST.
Denmark
Address

Roskilde
Deutsches Krebsforschungszentrum
Germany
Address
Im Neuenheimer Feld 280
69120 Heidelberg
FREIE UNIVERSITÄT BERLIN
Germany
Address

Berlin
HOSPITAL UNIVERSITARIO "LA FE"
Spain
Address
Avenida Campanar 21
46009 Valencia
Head of the Unit of Foodborne Zoonoses and Veterinary Epidemiology
Italy
Address
Viale Regina Elena 299
00161 Rome
Institut National de la Recherche Agronomique (INRA)
France
Address

31931 Toulouse
KAROLINSKA INST.
Sweden
Address
P.o. Box 60400
10401 Stockholm
NATIONAL INST. OF OCCUPATIONAL HEALTH
Norway
Address
Postbus 8149
33 Oslo
NESTEC LTD.
Switzerland
Address
P.o. Box 44
1000 Lausanne
RIKILT-DLO
Netherlands
Address

Wageningen
TEAGASC
Ireland
Address

Dublin
UNIVERSITA DEGLI STUDI DELLA TUSCIA
Italy
Address

Viterbo
UNIVERSITY OF STRATHCLYDE
United Kingdom
Address
16, Richmond Street
Glasgow
UNIVERSITÄT LEIPZIG
Germany
Address

Leipzig