DEVELOPMENT OF METABOLICALLY COMPETENT IN VITRO MODELS FOR FOOD SAFETY EVALUATION

Objective

The overall objective is to develop in vitro assays using immortalised human cell lines for increased food safety. Specifically this will be achieved by fulfilling the following objectives:

- developing immortalised cell lines from human target organs and characterising their metabolic competence in comparison with normal tissues - correcting metabolic deficiencies in the developed cell lines by genetic manipulation
- establishing assays for cytoxicity, genotoxicity and malignant transformation using the developed cell lines.

Completion of this project will allow more rapid prediction of target organ-specific harmful or beneficial effects of food, including contaminants and additives. It will contribute to reduction, refinement and eventual replacement of animal tests.

Fields of science

• medical and health sciences › medical biotechnology › genetic engineering
• engineering and technology › other engineering and technologies › food technology › food safety

Programme(s)

• FP3-AIR - Specific research and technological development and demonstration programme (EEC) in the field of agriculture and agro-industry, including fisheries, 1990-1994

Topic(s)

• 411 - Consumer safety

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Unilever UK Central Resources Ltd

Address

Colworth House
MK44 1LQ Sharnbrook
United Kingdom

Links

Participants (14)

DANISH MEAT RESEARCH INST.

Denmark

Address

Roskilde

Links

Deutsches Krebsforschungszentrum

Germany

Address

Im Neuenheimer Feld 280
69120 Heidelberg

Links

FREIE UNIVERSITÄT BERLIN

Germany

Address

Berlin

Links

HOSPITAL UNIVERSITARIO "LA FE"

Spain

Address

Avenida Campanar 21
46009 Valencia

Links

Head of the Unit of Foodborne Zoonoses and Veterinary Epidemiology

Italy

Address

Viale Regina Elena 299
00161 Rome

Links

Institut National de la Recherche Agronomique (INRA)

France

Address

31931 Toulouse

Links

KAROLINSKA INST.

Sweden

Address

P.o. Box 60400
10401 Stockholm

Links

NATIONAL INST. OF OCCUPATIONAL HEALTH

Norway

Address

Postbus 8149
33 Oslo

Links

NESTEC LTD.

Switzerland

Address

P.o. Box 44
1000 Lausanne

Links

RIKILT-DLO

Netherlands

Address

Wageningen

Links

TEAGASC

Ireland

Address

Dublin

Links

UNIVERSITA DEGLI STUDI DELLA TUSCIA

Italy

Address

Viterbo

Links

UNIVERSITY OF STRATHCLYDE

United Kingdom

Address

16, Richmond Street
Glasgow

Links

UNIVERSITÄT LEIPZIG

Germany

Address

Leipzig

Links