Objective
The overall objective is to develop in vitro assays using immortalised human cell lines for increased food safety. Specifically this will be achieved by fulfilling the following objectives:
- developing immortalised cell lines from human target organs and characterising their metabolic competence in comparison with normal tissues - correcting metabolic deficiencies in the developed cell lines by genetic manipulation
- establishing assays for cytoxicity, genotoxicity and malignant transformation using the developed cell lines.
Completion of this project will allow more rapid prediction of target organ-specific harmful or beneficial effects of food, including contaminants and additives. It will contribute to reduction, refinement and eventual replacement of animal tests.
Topic(s)
Funding Scheme
CSC - Cost-sharing contractsCoordinator
MK44 1LQ Sharnbrook
United Kingdom
Participants (14)
Roskilde
69120 Heidelberg
Berlin
46009 Valencia
00161 Rome
31931 Toulouse
10401 Stockholm
33 Oslo
1000 Lausanne
Wageningen
Dublin
Viterbo
Glasgow
Leipzig