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Content archived on 2024-04-19

DEVELOPMENT OF METABOLICALLY COMPETENT IN VITRO MODELS FOR FOOD SAFETY EVALUATION

Objective



The overall objective is to develop in vitro assays using immortalised human cell lines for increased food safety. Specifically this will be achieved by fulfilling the following objectives:

- developing immortalised cell lines from human target organs and characterising their metabolic competence in comparison with normal tissues - correcting metabolic deficiencies in the developed cell lines by genetic manipulation
- establishing assays for cytoxicity, genotoxicity and malignant transformation using the developed cell lines.

Completion of this project will allow more rapid prediction of target organ-specific harmful or beneficial effects of food, including contaminants and additives. It will contribute to reduction, refinement and eventual replacement of animal tests.

Call for proposal

Data not available

Coordinator

Unilever UK Central Resources Ltd
EU contribution
No data
Address
Colworth House
MK44 1LQ Sharnbrook
United Kingdom

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Total cost
No data

Participants (14)