DEVELOPMENT OF METABOLICALLY COMPETENT IN VITRO MODELS FOR FOOD SAFETY EVALUATION

Project Information

Grant agreement ID: AIR20860

Project closed

Start date 1 December 1993

End date 30 November 1996

Funded under

• Specific research and technological development and demonstration programme (EEC) in the field of agriculture and agro-industry, including fisheries, 1990-1994

Total cost € 4 421 577,00

EU contribution € 2 000 181,00

Coordinated by

Unilever UK Central Resources Ltd
United Kingdom

Objective

The overall objective is to develop in vitro assays using immortalised human cell lines for increased food safety. Specifically this will be achieved by fulfilling the following objectives:

- developing immortalised cell lines from human target organs and characterising their metabolic competence in comparison with normal tissues - correcting metabolic deficiencies in the developed cell lines by genetic manipulation
- establishing assays for cytoxicity, genotoxicity and malignant transformation using the developed cell lines.

Completion of this project will allow more rapid prediction of target organ-specific harmful or beneficial effects of food, including contaminants and additives. It will contribute to reduction, refinement and eventual replacement of animal tests.

Fields of science

• medical and health sciences › medical biotechnology › genetic engineering
• engineering and technology › other engineering and technologies › food technology › food safety

Programme(s)

• FP3-AIR - Specific research and technological development and demonstration programme (EEC) in the field of agriculture and agro-industry, including fisheries, 1990-1994

Topic(s)

• 411 - Consumer safety

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Unilever UK Central Resources Ltd

• EU contribution: No data
• Address: Colworth House ; MK44 1LQ Sharnbrook ; United Kingdom
• Total cost: No data

Participants (14)

DANISH MEAT RESEARCH INST.

Denmark

• EU contribution: No data
• Address: ROSKILDE
• Total cost: No data

Deutsches Krebsforschungszentrum

Germany

• EU contribution: No data
• Address: Im Neuenheimer Feld 280 ; 69120 Heidelberg
• Total cost: No data

FREIE UNIVERSITÄT BERLIN

Germany

• EU contribution: No data
• Address: BERLIN
• Total cost: No data

HOSPITAL UNIVERSITARIO "LA FE"

Spain

• EU contribution: No data
• Address: AVENIDA CAMPANAR 21 ; 46009 VALENCIA
• Total cost: No data

Head of the Unit of Foodborne Zoonoses and Veterinary Epidemiology

Italy

• EU contribution: No data
• Address: Viale Regina Elena 299 ; 00161 Rome
• Total cost: No data

Institut National de la Recherche Agronomique (INRA)

France

• EU contribution: No data
• Address: 31931 Toulouse
• Total cost: No data

KAROLINSKA INST.

Sweden

• EU contribution: No data
• Address: P.O. BOX 60400 ; 10401 STOCKHOLM
• Total cost: No data

NATIONAL INST. OF OCCUPATIONAL HEALTH

Norway

• EU contribution: No data
• Address: POSTBUS 8149 ; 33 OSLO
• Total cost: No data

NESTEC LTD.

Switzerland

• EU contribution: No data
• Address: P.O. BOX 44 ; 1000 LAUSANNE
• Total cost: No data

RIKILT-DLO

Netherlands

• EU contribution: No data
• Address: WAGENINGEN
• Total cost: No data

TEAGASC

Ireland

• EU contribution: No data
• Address: DUBLIN
• Total cost: No data

UNIVERSITA DEGLI STUDI DELLA TUSCIA

Italy

• EU contribution: No data
• Address: VITERBO
• Total cost: No data

UNIVERSITY OF STRATHCLYDE

United Kingdom

• EU contribution: No data
• Address: 16, Richmond Street ; GLASGOW
• Total cost: No data

UNIVERSITÄT LEIPZIG

Germany

• EU contribution: No data
• Address: LEIPZIG
• Total cost: No data