Skip to main content

PROTECTIVE IMMUNE RESPONSE AGAINST AFRICAN SWINE FEVER VIRUS

Objective



The objectives: the design of a strategy capable of including a protective immune response against African swine fever virus (ASFV) in domestic pigs.
Specific objectives are:
- Isolation of ASFV genes encoding proteins recognised by ASFV- neutralising antisera.
- Characterisation of the expression of the selected ASFV genes during the virus replicative cycle and the analysis of their possible involvement in virus morphogenesis.
- Assessment of the potential of selected ASFV proteins to induce a protective immune response against ASFV in domestic pigs.
- Assessment of the potential of vaccinia virus recombinants to elicit protective immune responses against ASFV infection.
- Characterisation of pig cell-mediated immune responses against ASFV infection, and the development of T-cell lines and clones recognising ASFV-infected cells.
- Development of a battery of new biological tools for the study of African swine fever and other diseases affecting domestic pigs.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSIDAD AUTONOMA
Address
Canto Blanco
28049 Madrid
Spain

Participants (4)

FUNDACAO CALOUSTE GULBENKIAN
Portugal
Address
Avenida De Berna 45A
1093 Oeiras
INIA
Spain
Address
Apartado De Correos 8111
28040 Madrid
INSTITUTE FOR ANIMAL HEALTH
United Kingdom
Address
High Street,compton
RG20 7NN Newbury
UNIVERSIDAD DE SALAMANCA
Spain
Address
Patio De Escuelas, 1
Salamanca