Objective
The object of the study is to use specific probes to identify the surface antigens and life cycle stages of PK"X", the causative agent of PKD, so that an effective vaccine against the disease can be developed. In addition, the distribution and level of the disease in Europe will be established. Monoclonal antibody and lectin probes will be used to identify and quantify the parasite in fish tissues and water samples collected during the PKD season throughout the course of the project. Monoclonal antibody probes, developed during the "FAR" project, will be used to purify PK"X" cell antigen from host cells using affinity chromatography. These will be used to inject mice and produce a further battery of monoclonal antibodies to different surface antigens. Such probes will be used in life-cycle studies and enable identification of life-cycle stages prior to those currently identified using histological methods. The detailed immune response of fish following natural PKD infection will be investigated. ELISA and dot-filter tests will also be used to detect specific PK"X" cells from water samples by linking monoclonal antibodies to filters. Such material will then be used in attempts at culture of the PK"X" cells in vitro. A series of passive immunisation experiments will be carried out to establish the nature of the protective antigens. This information will then be used to formulate and field test potential vaccines.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology immunisation
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences clinical medicine nephrology kidney diseases
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
FK9 4LA STIRLING
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.