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Contenido archivado el 2024-04-15

THE DEVELOPMENT OF TRANSGENIC ANIMALS (INCLUDING FISH) WITH NOVEL CHARACTERISTICS

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultados aprovechables

Regulatory sequence from several rabbit milk protein genes have been identified. One of them, from the WAP gene (whey acidic protein) is highly efficient to direct the expression of foreign genes in the mammary gland. The rabbit WAP gene promotor has been patented. Several recombinant proteins of pharmaceutical interest have been produced in the milk of transgenic mice and rabbits (human and bovine growth hormones, EC superoxide dismutase, erythropoietin) some of them at a high level. Several litres of rabbit milk have been collected for some of the proteins. Vectors optimized for the expression of foreign genes in the mammary gland are prepared. Transgenic rabbits used as models in biomedical studies have been obtained (AIDS, atherosclerosis) and others are being prepared. In addition methods to obtain transgenic trout have been defined and promotors working in fish cells have been determened.

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