THE DEVELOPMENT OF TRANSGENIC ANIMALS (INCLUDING FISH) WITH NOVEL CHARACTERISTICS

Projektinformationen

ID Finanzhilfevereinbarung: BAP*0179

Projekt abgeschlossen

Startdatum 1 Juli 1986

Enddatum 31 Dezember 1989

Finanziert unter

• Multiannual research action programme (EEC) in the field of biotechnology (BAP), 1985-1989

Gesamtkosten

Keine Daten

EU-Beitrag

Keine Daten

Koordiniert durch

Institut National de la Recherche Agronomique (INRA)
France

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Verwertbare Ergebnisse

Use of foreign gene promoters in transgenic animals

Regulatory sequence from several rabbit milk protein genes have been identified. One of them, from the WAP gene (whey acidic protein) is highly efficient to direct the expression of foreign genes in the mammary gland. The rabbit WAP gene promotor has been patented. Several recombinant proteins of pharmaceutical interest have been produced in the milk of transgenic mice and rabbits (human and bovine growth hormones, EC superoxide dismutase, erythropoietin) some of them at a high level. Several litres of rabbit milk have been collected for some of the proteins. Vectors optimized for the expression of foreign genes in the mammary gland are prepared. Transgenic rabbits used as models in biomedical studies have been obtained (AIDS, atherosclerosis) and others are being prepared. In addition methods to obtain transgenic trout have been defined and promotors working in fish cells have been determened.