MECHANISM OF RADIATION-INDUCED LEUKOMOGENESIS AND OSTEOSARCOMA- GENESIS

Project Information

Grant agreement ID: BI6*0090

Project closed

Start date 1 January 1985

End date 31 December 1989

Funded under

• Multiannual research and training programme (Euratom) in the field of radiation protection, 1985-1989

Total cost No data

EU contribution No data

Coordinated by

CENTRE D'ETUDES DE L'ENERGIE NUCLEAIRE
Belgium

Objective

Activation mechanisms in tumour cells were investigated by looking at receptors for neurotrasmitters and hormones coupled to adenylate cyclase. Lymphomas (induced by radiation or by RadLV) expressed at least one such receptor, either beta adrenergic or vasoactive intestinal peptide (VIP) -ergic. Receptors for VIP are remarkable since they are of the helodermin preferring type.
In conclusion, our cellular and biochemical studies have documented the production of insulin like growth factor (IGF) 2 by radiation induced lymphomas. Interleukin (IL) 1, IL-6, or IL-2 do not play a critical role in lymphomagenesis. Lymphoma cells express receptors for hormones or neurotransmitters coupled to adelnyate cyclase.
1. MECHANISMS OF RADIATION-INDUCED LEUKEMOGENESIS.
2. MOLECULAR BIOLOGY OF RADIATION-INDUCED OSTEOSARCOMAGENESIS. ROLE OF ONCOGENES AND VIRUSES.

Fields of science

Not validated

• natural sciences › biological sciences › microbiology › virology
• natural sciences › biological sciences › biochemistry › biomolecules
• natural sciences › biological sciences › molecular biology

Programme(s)

• FP1-RADPROT 6C - Multiannual research and training programme (Euratom) in the field of radiation protection, 1985-1989

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE D'ETUDES DE L'ENERGIE NUCLEAIRE

• EU contribution: No data
• Address: RUE CHARLES LEMAIRE 1 ; 1160 BRUSSELS ; Belgium
• Total cost: No data