Objective
Activation mechanisms in tumour cells were investigated by looking at receptors for neurotrasmitters and hormones coupled to adenylate cyclase. Lymphomas (induced by radiation or by RadLV) expressed at least one such receptor, either beta adrenergic or vasoactive intestinal peptide (VIP) -ergic. Receptors for VIP are remarkable since they are of the helodermin preferring type.
In conclusion, our cellular and biochemical studies have documented the production of insulin like growth factor (IGF) 2 by radiation induced lymphomas. Interleukin (IL) 1, IL-6, or IL-2 do not play a critical role in lymphomagenesis. Lymphoma cells express receptors for hormones or neurotransmitters coupled to adelnyate cyclase.
1. MECHANISMS OF RADIATION-INDUCED LEUKEMOGENESIS.
2. MOLECULAR BIOLOGY OF RADIATION-INDUCED OSTEOSARCOMAGENESIS. ROLE OF ONCOGENES AND VIRUSES.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1160 BRUSSELS
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.