Objective
The use of hemopoietic growth factors for irradiation therapy have been investigated. Although a relationship between the early GM-CSF response and the dose of irradiation could be established, the variability of response and slow response time made use of GM-CSF impractical. However, GM-CSF was totally effective against leukopenia after a radiation dose of 5 Gy total body irradiation (about 2-log stem cell depletion), but it became increasingly less effective at higher doses of irradiation. Studies with the much more broadly acting growth factor IL-3, were also carried out. Molecular cloning and production of rhesus monkey IL-3 was successfully achieved and preclinical pilot studies, using unirradiated monkeys, have been completed. The positive selection of hemopoietic stem cells was also achieved, by developing a large-scale method based on selection of CD34+ cells. These preparations have been successfully tested in autologous transplantation experiments.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine transplantation
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2280 HV RIJSWIJK
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.