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Generation of transgenic and knock out animal models relevant to the study of human health

Objective

The overall project is based on the study of mouse models generated with the gene targeting and the transgenic technology in order to investigate the mechanism of immune responsiveness and unresponsiveness relevant to autoimmunity.
Studies on the following mouse models have been carried out:
1) Lysozyme transgenic mice.
2) TcR (anti-IgG2a{b}) transgenic mice.
3) beta2-microglobulin gene deficient mice.
4) A CD3-epsilon gene deficient mice.
5) Cell type specific Cre recombinase gene transgenic mice; cytokine receptor gene mutants carrying 'floxed gene' for conditional knock out mice.
1) Tg mouse model of controlled autoimmune disease
2) Tg mouse model of class II restricted self antigen (Ig) presentation
3) A mouse model of Th1/Th2 polarization
4) A CD3 mutated mouse model for thymic selection
5) New cre-recombinase Tg mouse lines useful for the application of somatic gene alteration.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT PASTEUR
Address
25,Rue Du Docteur Roux 28
75724 Paris
France

Participants (4)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Parc Scientifique Et Technologique De Luminy
13288 Marseille
Roche SpA
Italy
Address
Piazza Durante 11
20131 Milano
Università degli Studi di Milano
Italy
Address
Via Vanvitelli 32
20129 Milano
Universität Köln
Germany
Address
Weyertal 121
50931 Köln