Objective
Complementary strategies to identify diabetes genes will be applied, such as 1) random mapping of the total human genome from several hundred well-characterized NIDDM families, with highly informative DNA markers for a systematic search for chromosomal regions co-segregating in subtypes of NIDDM, 2) positional cloning in cases where chromosomal localization does not reveal known candidate genes, 3) cloning of a series of candidate genes and screening of these genes for disease-causing mutations, 4) identification of new NIDDM candidate genes by mRNA-differential display in muscle biopsies from insulin resistant NIDDM-patients, 5) genetic studies of animal modes, eg. the GK-rat, and extrapolation of the results to human NIDDM and 6) studies of early onset NIDDM families (MODY) which are negative for linkage to glucokinase or adenosine deaminase genes. Defining the nature of the NIDDM genes will allow early identification of high risk individuals who may benefit from early medical intervention and thereby the prevention of NIDDM in many cases. Knowledge of the genetics of NIDDM will also give the basis for the development of specifically targeted antidiabetic drugs and/or gene therapy in some cases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
59019 LILLE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.