Cel Complementary strategies to identify diabetes genes will be applied, such as 1) random mapping of the total human genome from several hundred well-characterized NIDDM families, with highly informative DNA markers for a systematic search for chromosomal regions co-segregating in subtypes of NIDDM, 2) positional cloning in cases where chromosomal localization does not reveal known candidate genes, 3) cloning of a series of candidate genes and screening of these genes for disease-causing mutations, 4) identification of new NIDDM candidate genes by mRNA-differential display in muscle biopsies from insulin resistant NIDDM-patients, 5) genetic studies of animal modes, eg. the GK-rat, and extrapolation of the results to human NIDDM and 6) studies of early onset NIDDM families (MODY) which are negative for linkage to glucokinase or adenosine deaminase genes. Defining the nature of the NIDDM genes will allow early identification of high risk individuals who may benefit from early medical intervention and thereby the prevention of NIDDM in many cases. Knowledge of the genetics of NIDDM will also give the basis for the development of specifically targeted antidiabetic drugs and/or gene therapy in some cases. Dziedzina nauki medical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineendocrinologydiabetesnatural sciencesbiological sciencesgeneticsmutationnatural sciencesbiological sciencesgeneticsgenomes Program(-y) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Temat(-y) 5.3 - Role of gene and gene products in disease aetiology and pathogenesis Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Wkład UE Brak danych Adres 1,Rue du Professeur Calmette 1 59019 LILLE Francja Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Institut National de la Santé et de la Recherche Médicale Francja Wkład UE Brak danych Adres 1,Avenue Claude Vellefaux 75475 Paris Zobacz na mapie Koszt całkowity Brak danych Lund University Szwecja Wkład UE Brak danych Adres 214 01 Malmö Zobacz na mapie Koszt całkowity Brak danych NOVO-NORDISK A/S Dania Wkład UE Brak danych Adres Niels Steensens Vej 2 2820 GENTOFFE Zobacz na mapie Koszt całkowity Brak danych THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Zjednoczone Królestwo Wkład UE Brak danych Adres Roosevelt Drive OX3 7BN OXFORD/HEADINGTON Zobacz na mapie Koszt całkowity Brak danych Université de Paris VII Francja Wkład UE Brak danych Adres 2,Place Jussieu 75251 Paris Zobacz na mapie Koszt całkowity Brak danych
