CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
Exploitable results
Our project is concerned with front-line molecular and cellular studies of the biosynthesis of leukotrienes, powerful lipid mediators of inflammation and allergy. During our project, we have been able to solve the crystal structure of a key enzyme in the biosynthetic cascade. This achievement makes it possible to start rational, structure-based, design of enzyme inhibitors, compounds that can be developed into novel anti-flammatory drugs. In addition, hitherto unknown regulatory mechanisms of the leukottriene cascade have been unraveled, which in turn has allowed us to identify new potential drug targets
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