Objetivo To integrate in vitro tests or models, based on human liver-derived systems. for predicting the metabolism and metabolic interactions of drugs and chemicals which are likely to occur following their exposure in man and compare these with results in vivo.Detailed knowledge of the metabolism of pharmaceuticals is essential as early as possible in the research and development process, for two main reasons. The metabolism of drugs is generally the major determinant of their pharmacokinetic behaviour, interindividual variability and interactions with other compounds, all factors that complicate drug treatment. Differences in metabolism are also very often responsible for difficulties in extrapolating from a toxicology test species to humans, which can be a serious obstacle in drug testing and development.A large number of approaches, based largely, but not solely on human-derived systems, for the prediction of drug metabolism are under development, although not all areas are as well advanced as some. The project will involve the selection or development of suitable model substances and reagents which will be used to define rigorously the various candidate in vitro methods and approaches, the application of the most promising methods and approaches to existing drugs and substances under development, i.e. "real" compounds from the participating industrial laboratories, and a comparison of the predictive power of these approaches to metabolism in vivo, determined in volunteers. The likely outcome is the identification of suitable tests, and the development of an integrated approach to the prediction of the metabolism of drugs. This could be used in drug discovery, in the design and execution of toxicity tests and of early clinical trials.Other major tangible benefits will accrue, such as a decrease in the cost of drug development and acceleration of the process, because clinical studies could be targeted on the basis of in vitro results. The project will help to reduce the number of animals required currently in the preclinical development of pharmaceuticals. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesbasic medicinetoxicology Programa(s) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Tema(s) 1.1 - Pharmacotoxicology Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador University of Oulu Aportación de la UE Sin datos Dirección 52 D,KAJAANINTIE 90220 OULU Finlandia Ver en el mapa Coste total Sin datos Participantes (11) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Almirall-Prodesfarma España Aportación de la UE Sin datos Dirección Sant Just Desvern Ver en el mapa Coste total Sin datos Astra Hässle AB Suecia Aportación de la UE Sin datos Dirección Astra Hassleab 431 83 MOLNDAL Ver en el mapa Coste total Sin datos BIBRA International Reino Unido Aportación de la UE Sin datos Dirección Woodmansterne Road SM5 4DS Carshalton Ver en el mapa Coste total Sin datos Böhringer Mannheim GmbH Alemania Aportación de la UE Sin datos Dirección 116,SANDHOFER STRASSE 68298 MANNHEIM Ver en el mapa Coste total Sin datos Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg Alemania Aportación de la UE Sin datos Dirección 1,NIKOLAI-FUCHS-STRASSE 30625 HANNOVER Ver en el mapa Coste total Sin datos Hospital Universitario de la Fe 'Sevasa' España Aportación de la UE Sin datos Dirección 21,Avenida Campanar 46009 Valencia Ver en el mapa Coste total Sin datos Karolinska Institute Suecia Aportación de la UE Sin datos Dirección 6A,Berzelins Laboratory 171 77 STOCKHOLM Ver en el mapa Coste total Sin datos Orion Corporation Ltd. Finlandia Aportación de la UE Sin datos Dirección 425,P.O.Box 20101 TURKU Ver en el mapa Coste total Sin datos Royal Postgraduate Medical School Reino Unido Aportación de la UE Sin datos Dirección Du Cane Road W12 0NN London Ver en el mapa Coste total Sin datos UNIVERSITY OF SURREY Reino Unido Aportación de la UE Sin datos Dirección GU2 7XH GUILDFORD Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Université de Rennes I Francia Aportación de la UE Sin datos Dirección 101,Rue de Tolbiac 75654 PARIS Ver en el mapa Coste total Sin datos