Objective
- To prepare replicates of the CEPH bacterial artificial chromosome (BAC) genomic library and send these to partners in Italy, Germany and the United Kingdom.
- To place about 4,000 sequence tagged sites (STS) and other markers on BAC clones of this library.
- To assemble at CEPH a public physical mapping database that contains data concerning these clones featuring the STSs/other markers that they contain.
The overall objective of this project is to provide a mapping resource for constructing sequence-ready physical maps by characterising in the European Union the genomic human BAC library developed at the Fondation Jean Dausset- CEPH. The CEPH BAC library contains approximately 200,000 clones obtained by cloning partial BamHI or HindIII partial digests into BAC vector pBeloBAC. The mean insert size of the BAC clones is 126 kb (15% of clones without inserts not included for the estimate), and the mean genome redundancy is estimated at 7.9. The BAC library will be maintained and managed at CEPH. A copy of the library will be sent to each of the partners for characterisation of clones. Four partners will characterise the library by testing the BAC clones for already known and new STS and hybridization based markers with a total of approximately 4,000 markers/STSs. The partners will coordinate efforts to minimise overlap of STSs used to characterise the BAC library. All data accruing from this project will be deposited in a database that CEPH will make publicly available in a timely fashion. This project will deliver a valuable mapping resource, for positional cloning activities and, especially, for sequencing the human genome.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Coordinator
75010 PARIS
France
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