Skip to main content
European Commission logo
English English
CORDIS - EU research results
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary
Content archived on 2024-05-14

Cellular and molecular requirements for growth of sensory axons into the spinal cord

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Exploitable results

Injured nerve fibres in the spinal cord are unable to regenerate. Consequently, individuals who have sustained such injuries suffer from lifelong and seriously disabling loss of sensory and/or motor functions. The project has addressed the problem of overcoming spinal cord regeneration failure, focusing on the injuries to the fibres which convey sensory impulses from the periphery to the spinal cord. These fibres fail to re-enter the spinal cord after injury. The teams have provided convincing experimental evidence that this regeneration failure can be overcome by: 1) Replacing the injured neurons with embryonic nerve cells. 2) Immediate administration of specific growth factors. 3) The implantation of growth-promoting non-neuronal cells at the place where these fibres normally enter the spinal cord. Although additional experimental work is needed, the results obtained justify an optimistic long term view on the possibilities in a future to restore some degree of sensory functions in patients with brachial plexus avulsion, the clinical condition resembling the experimental models explored in the project.

Searching for OpenAIRE data...

There was an error trying to search data from OpenAIRE

No results available