Prediction and assessment of the aquatic toxicity of mixtures of chemicals

Project Information

PREDICT

Grant agreement ID: ENV4960319

Project closed

Start date 1 January 1997

End date 31 December 1999

Funded under

• Specific programme of research and technological development in the field of environment and climate, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

UNIVERSITAET BREMEN
Germany

Objective

Surface waters and aquatic organisms are typically exposed to numerous chemicals simultaneously or in sequence. Consequently, hazard assessment in aquatic toxicology has to include rational approaches to predict possible combination effects. Different concepts allow to calculate expected toxicities of mixtures by analysis of concentration response relationships of their components.
The recent report to the Scientific Advisory Committee on Toxicology and Ecotoxicology of the EEC concluded that the concept of concentration addition provides a reasonable basis to predict combined effects of similar acting substances. It should be applied when environmental quality norms are set. However, three questions remain to be answered:
- Which criteria shall be used to classify substances as similar acting?
- Is the concept of concentration addition valid for the prediction of mixture toxicities on more complex than single species levels?
- What are reasonable predictions for combined effects of substances with dissimilar modes of action?
The objectives of the research project PREDICT are:
- to avaluate the potential of quantitative structure activity relationships (QSAR) for the prospective assessment of mixture toxicities and to optimise grouping criteria for pollutants like the list 1 chemicals of directive 76/464/EEC.
- to experimentally validate predictions made from the concept of concentration addition for similar acting substances on a periphyton multispecies community test level, and
- to compare the predictive values of the concepts of ,concentration addition and independent action for multi-component combinations of dissimilar acting substances especially for low, non-significant effect concentrations (EC1%) of the individual constituents.
D. Calamari & M. Vighi (1991),EEC contract B 6612-90-001297
KEYWORDS :
mixture toxicity; prediction; aquatic toxicology.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• medical and health sciences › health sciences › public health
• social sciences › sociology › governance › crisis management
• medical and health sciences › basic medicine › toxicology

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Programme(s)

• FP4-ENV 2C - Specific programme of research and technological development in the field of environment and climate, 1994-1998

Topic(s)

• 02020102 - Risks to the environment

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITAET BREMEN

• EU contribution: No data
• Address: 2,Loebener Strasse 2 ; 28344 BREMEN ; Germany
• Total cost: No data

Participants (2)

GOETEBORG UNIVERSITY

Sweden

• EU contribution: No data
• Address: 22B,Carl Skottsbergs Gata 22B ; 413 19 GOETEBORG
• Total cost: No data

Università degli Studi di Milano

Italy

• EU contribution: No data
• Address: Via Celoria 2 ; 20133 Milano
• Total cost: No data