Cel Surface waters and aquatic organisms are typically exposed to numerous chemicals simultaneously or in sequence. Consequently, hazard assessment in aquatic toxicology has to include rational approaches to predict possible combination effects. Different concepts allow to calculate expected toxicities of mixtures by analysis of concentration response relationships of their components. The recent report to the Scientific Advisory Committee on Toxicology and Ecotoxicology of the EEC concluded that the concept of concentration addition provides a reasonable basis to predict combined effects of similar acting substances. It should be applied when environmental quality norms are set. However, three questions remain to be answered: - Which criteria shall be used to classify substances as similar acting? - Is the concept of concentration addition valid for the prediction of mixture toxicities on more complex than single species levels? - What are reasonable predictions for combined effects of substances with dissimilar modes of action? The objectives of the research project PREDICT are: - to avaluate the potential of quantitative structure activity relationships (QSAR) for the prospective assessment of mixture toxicities and to optimise grouping criteria for pollutants like the list 1 chemicals of directive 76/464/EEC. - to experimentally validate predictions made from the concept of concentration addition for similar acting substances on a periphyton multispecies community test level, and - to compare the predictive values of the concepts of ,concentration addition and independent action for multi-component combinations of dissimilar acting substances especially for low, non-significant effect concentrations (EC1%) of the individual constituents. D. Calamari & M. Vighi (1991),EEC contract B 6612-90-001297 KEYWORDS : mixture toxicity; prediction; aquatic toxicology. Dziedzina nauki medycyna i nauki o zdrowiunauki o zdrowiuzdrowie publiczne i środowiskowenauki społecznesocjologiaadministracjazarządzanie kryzysowemedycyna i nauki o zdrowiumedycyna klinicznatoksykologia Program(-y) FP4-ENV 2C - Specific programme of research and technological development in the field of environment and climate, 1994-1998 Temat(-y) 02020102 - Risks to the environment Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator UNIVERSITAET BREMEN Adres 2,loebener strasse 2 28344 Bremen Niemcy Zobacz na mapie Wkład UE Brak danych Uczestnicy (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko GOETEBORG UNIVERSITY Szwecja Wkład UE € 0,00 Adres 22b,carl skottsbergs gata 22b 413 19 Goeteborg Zobacz na mapie Środki z innych źródeł Brak danych Università degli Studi di Milano Włochy Wkład UE € 0,00 Adres Via celoria 2 20133 Milano Zobacz na mapie Środki z innych źródeł Brak danych
