Objetivo DEVELOPMENT AND VALIDATION OF ASSAYS TO EVALUATE CHEMICALS CAPABLE OF INDUCING GENOMIC MUTATIONS. EMPHASIS IS GIVEN TO THE FUNGUS ASPERGILLUS NIDULANS, WHICH OFFERS CONSIDERABLE PROMISE AS A SYSTEM FOR DETECTING GENOMIC MUTATIONS AND FOR UNDERSTANDING THE MECHANISMS OF SUCH MUTATION. THE WORK INCLUDES : I) THE USE OF THE DIPLOID STRAIN OF A NIDULANS TO DETECT CHEMICALLY INDUCED EUPLOID MITOTIC SEGREGANTS AS PRODUCTS OF NON-DISJUNCTION OR MITOTIC CROSSING-OVER. II) THE SYNTHESIS OF MARKED DIPLOID STRAINS TO DISTINGUISH INDUCED ANEUPLOIDY FROM CHROMOSOME BREAKS. III) INVESTIGATING THE POSSIBILITY OF USING METABOLIC ACTIVATION IN THE SYSTEM. IV) ESTABLISHING THE EFFECTS OF ANEUGENIC CHEMICALS ON TUBULIN ASSEMBLY. Ámbito científico natural sciencesbiological sciencesmicrobiologymycologynatural sciencesbiological sciencesgeneticsmutationnatural sciencesearth and related environmental sciencesenvironmental sciencespollutionnatural sciencesbiological sciencesgeneticschromosomes Programa(s) FP1-ENVPROT 4C - Multiannual research and development programmes (EEC) in the field of the environment - Protection of the environment -, 1986-1990 Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador Greek Atomic Energy Commission Aportación de la UE Sin datos Dirección Attikis 15310 Athens Grecia Ver en el mapa Coste total Sin datos
