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Contenido archivado el 2024-04-19

Validation of early markers of nephrotoxicity for detecting groups at risk in the general population: application to children

Objetivo

The goal of this programme is to assess various tests of renal function with a view to their increasing use in preventive medicine and the screening of "at-risk" groups. A battery of tests for the early detection of renal dysfunction will be monitored in a vulnerable section of the population, namely children. This information will help the group to set reference ranges for the non-invasive tests under study for children and to compare them to those already established for adults.


The project will validate the battery of tests which proved most useful in the previous STEP II Programme by examining children. Unlike the cohorts previously studied, the children which are the subject of Phase II have not been directly exposed but are living in an area of industrial pollution. The emphasis is therefore a long-term environmental exposure rather than exposure due to work practice. There may also be advantages in studying children in that life style factors such as smoking, drug consumption and degenerative diseases are less important. 400 children (10-12 years of age) living in polluted or non-polluted areas of Germany, Italy and Belgium will be studied. Collected urine samples will be distributed using the procedures developed in STEP II and questionnaire data collected by trained interviewers. The tests are chosen for their sensitivity and ability to target the site of nephrotoxic dysfunction/damage. Most important among the tests are urinary enzymes, prostaglandins, specific proteins, brush border antigens and breakdown products of the extracellular matrix. Several new tests will be introduced including protein 1, EGF, endothelins and eicosanoids.

Ámbito científico (EuroSciVoc)

Programa(s)

Tema(s)

Convocatoria de propuestas

Datos no disponibles

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

King's College London
Aportación de la UE
Sin datos
Dirección
Campden Hill Road
W8 7AH London
Reino Unido
Coste total
Sin datos

Participantes (5)