Objective
The goal of this programme is to assess various tests of renal function with a view to their increasing use in preventive medicine and the screening of "at-risk" groups. A battery of tests for the early detection of renal dysfunction will be monitored in a vulnerable section of the population, namely children. This information will help the group to set reference ranges for the non-invasive tests under study for children and to compare them to those already established for adults.
The project will validate the battery of tests which proved most useful in the previous STEP II Programme by examining children. Unlike the cohorts previously studied, the children which are the subject of Phase II have not been directly exposed but are living in an area of industrial pollution. The emphasis is therefore a long-term environmental exposure rather than exposure due to work practice. There may also be advantages in studying children in that life style factors such as smoking, drug consumption and degenerative diseases are less important. 400 children (10-12 years of age) living in polluted or non-polluted areas of Germany, Italy and Belgium will be studied. Collected urine samples will be distributed using the procedures developed in STEP II and questionnaire data collected by trained interviewers. The tests are chosen for their sensitivity and ability to target the site of nephrotoxic dysfunction/damage. Most important among the tests are urinary enzymes, prostaglandins, specific proteins, brush border antigens and breakdown products of the extracellular matrix. Several new tests will be introduced including protein 1, EGF, endothelins and eicosanoids.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences environmental sciences pollution
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
W8 7AH London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.