Objective A broad programme of research has been conducted including: - the determination of biokinetic data by measurement and literature review - the assessment of uncertainties in these parameters - the formulation of new biokinetic models - the development of computer codes for dose calculations. This work was performed in close collaboration with the ICRP Task Group on Internal Dosimetry, INDOS (formerly Age-dependent Dosimetry, AGDOS), and the ICRP Task Group on Dose Calculations.This proposal is an extension and development of the existing project "Inhalation and Ingestion of Radionuclides" (Bi6-0347b), carried out by organisations 01-07 listed below. Knowledge of organ doses following intakes of radionuclides is needed for control of occupational exposures, for assessing the consequenses of accidental and routine releases to the environment, in nuclear medicine, and in evaluating exposures to radon in both workplaces and homes. This project will: . Identify and address uncertainties in models used in radiation protection to evaluate organ doses from intakes of radionuclides. . In conjunction with ICRP Task Groups, develop more comprehensive, realistic and up-to-date models for relating intakes to organ doses, and for interpreting bioassay measurements. . Develop software to implement improved internal dosimetry models for the respiratory tract, gastrointestinal (GI) tract, bone and fetus. . Measure GI uptake and long term urinary excretion of Pu in man. . Measure human respiratory parameters and total respiratory tract deposition of particles in different ethnic groups. . Measure regional respiratory tract deposition of submicron and hygroscopic particles in man, and extend regional deposition models. . Continue to quantify particle clearance, and commence measurements of absorption into blood, from each region of the human respiratory tract. . Investigate the extent and duration of the slow phase of particle clearance from the human tracheobronchial tree. . Investigate mechanisms of slow tracheobronchial clearance: the functional morphology of human respiratory epithelium; the role of airway macrophages; the effect on particles clearing from the alveolar region. PARTICIPATING ORGANISATIONS 01 National Radiological Protection Board, NRPB (Bailey) (Co-ordinator) 02 Forschungszentrum für Umwelt und Gesundheit 03 Commissariat á l'Energie Atomique 04 Medical Research Council 05 NRPB (Kendall) 06 Bundesamt für Strahlenschutz 07 University of Wales, Cardiff 08 NRPB (Popplewell) 09 AEA Harwell Laboratory 10 TNO-Institute of Applied Radiobiology and Immunology Fields of science natural sciencesbiological sciencesbiological morphologyfunctional morphologymedical and health sciencesclinical medicineradiologynuclear medicinemedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineembryologynatural scienceschemical sciencesnuclear chemistryradiation chemistry Programme(s) FP3-NFS 1 - Research and education programme (Euratom) in the field of nuclear fission safety, 1990-1994 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator BUNDESAMT FUER STRAHLENSCHUTZ EU contribution No data Address 1,Ingolstädter Landstraße 1 85764 OBERSCHLEISSHEIM Germany See on map Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all NATIONAL RADIOLOGICAL PROTECTION BOARD United Kingdom EU contribution No data Address OX11 0RQ DIDCOT,HARWELL,CHILTON See on map Total cost No data Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek Netherlands EU contribution No data Address 310,Utrechtseweg 6800 ES Arnhem See on map Total cost No data University of Wales, Cardiff United Kingdom EU contribution No data Address CF1 3TB Cardiff See on map Total cost No data
