Cel A broad programme of research has been conducted including: - the determination of biokinetic data by measurement and literature review - the assessment of uncertainties in these parameters - the formulation of new biokinetic models - the development of computer codes for dose calculations. This work was performed in close collaboration with the ICRP Task Group on Internal Dosimetry, INDOS (formerly Age-dependent Dosimetry, AGDOS), and the ICRP Task Group on Dose Calculations.This proposal is an extension and development of the existing project "Inhalation and Ingestion of Radionuclides" (Bi6-0347b), carried out by organisations 01-07 listed below. Knowledge of organ doses following intakes of radionuclides is needed for control of occupational exposures, for assessing the consequenses of accidental and routine releases to the environment, in nuclear medicine, and in evaluating exposures to radon in both workplaces and homes. This project will: . Identify and address uncertainties in models used in radiation protection to evaluate organ doses from intakes of radionuclides. . In conjunction with ICRP Task Groups, develop more comprehensive, realistic and up-to-date models for relating intakes to organ doses, and for interpreting bioassay measurements. . Develop software to implement improved internal dosimetry models for the respiratory tract, gastrointestinal (GI) tract, bone and fetus. . Measure GI uptake and long term urinary excretion of Pu in man. . Measure human respiratory parameters and total respiratory tract deposition of particles in different ethnic groups. . Measure regional respiratory tract deposition of submicron and hygroscopic particles in man, and extend regional deposition models. . Continue to quantify particle clearance, and commence measurements of absorption into blood, from each region of the human respiratory tract. . Investigate the extent and duration of the slow phase of particle clearance from the human tracheobronchial tree. . Investigate mechanisms of slow tracheobronchial clearance: the functional morphology of human respiratory epithelium; the role of airway macrophages; the effect on particles clearing from the alveolar region. PARTICIPATING ORGANISATIONS 01 National Radiological Protection Board, NRPB (Bailey) (Co-ordinator) 02 Forschungszentrum für Umwelt und Gesundheit 03 Commissariat á l'Energie Atomique 04 Medical Research Council 05 NRPB (Kendall) 06 Bundesamt für Strahlenschutz 07 University of Wales, Cardiff 08 NRPB (Popplewell) 09 AEA Harwell Laboratory 10 TNO-Institute of Applied Radiobiology and Immunology Dziedzina nauki natural sciencesbiological sciencesbiological morphologyfunctional morphologymedical and health sciencesclinical medicineradiologynuclear medicinemedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineembryologynatural scienceschemical sciencesnuclear chemistryradiation chemistry Program(-y) FP3-NFS 1 - Research and education programme (Euratom) in the field of nuclear fission safety, 1990-1994 Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator BUNDESAMT FUER STRAHLENSCHUTZ Wkład UE Brak danych Adres 1,Ingolstädter Landstraße 1 85764 OBERSCHLEISSHEIM Niemcy Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (3) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko NATIONAL RADIOLOGICAL PROTECTION BOARD Zjednoczone Królestwo Wkład UE Brak danych Adres OX11 0RQ DIDCOT,HARWELL,CHILTON Zobacz na mapie Koszt całkowity Brak danych Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek Niderlandy Wkład UE Brak danych Adres 310,Utrechtseweg 6800 ES Arnhem Zobacz na mapie Koszt całkowity Brak danych University of Wales, Cardiff Zjednoczone Królestwo Wkład UE Brak danych Adres CF1 3TB Cardiff Zobacz na mapie Koszt całkowity Brak danych