The role of intercellular communication and DNA double strand breaks in the induction of bystander effects

Informations projet

INTERSTANDER

N° de convention de subvention: FIGH-CT-2002-00218

Date de début 1 Mars 2003

Date de fin 28 Février 2006

Financé au titre de

• Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002)

Coût total € 830 551,00

Contribution de l’UE € 700 000,00

Coordonné par

UNIVERSITY OF ESSEN
Germany

Objectif

The biological processes mediating bystander responses are incompletely understood despite the relevance of this phenomenon to radiation protection and radiation therapy. The present proposal contributes to the elucidation of the mechanisms underlying bystander effects by evaluating intercellular communication as a determinant of the response, and DNA double strand breaks as initiating lesions. Using biological model systems with conditional induction of intercellular communication and diverse experimental approaches, some of which are developed and tested here, we aim to investigate the induction kinetics of by stander effects in cultured cells and evaluate their contribution to the response of tumors growing in nude mice to ionizing radiation. The results should allow the definition of targets for pharmacological intervention to protect humans from the adverse effects of ionizing radiation.

Champ scientifique

• natural sciences › biological sciences › genetics › DNA
• natural sciences › physical sciences › nuclear physics

Programme(s)

• FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002)

Thème(s)

• 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate

Appel à propositions

Data not available

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

UNIVERSITY OF ESSEN

• Contribution de l’UE: Aucune donnée
• Adresse: Hufelandstrasse 55 ; 45147 ESSEN ; Allemagne
• Coût total: Aucune donnée

Participants (4)

BUNDESREPUBLIK DEUTSCHLAND

Allemagne

• Contribution de l’UE: Aucune donnée
• Adresse: Budensallee 100 ; 38116 BRAUNSCHWEIG
• Coût total: Aucune donnée

FACULTY OF MEDICINE/UNIVERSITY HOSPITAL GOETTINGEN

Allemagne

• Contribution de l’UE: Aucune donnée
• Adresse: Robert-Koch-Strasse 40 ; 37075 GOETTINGEN
• Coût total: Aucune donnée

NATIONAL CENTRE FOR SCIENTIFIC RESEARCH 'DEMOKRITOS'

Grèce

• Contribution de l’UE: Aucune donnée
• Adresse: Terma Patriarchou Grigoriou ; 15310 ATHENS
• Coût total: Aucune donnée

UNIVERSITY OF ST ANDREWS

Royaume-Uni

• Contribution de l’UE: Aucune donnée
• Adresse: Queen's Terrace Bute Medical Buildings ; KY16 9TS St Andrews, Fife
• Coût total: Aucune donnée