Obiettivo The biological processes mediating bystander responses are incompletely understood despite the relevance of this phenomenon to radiation protection and radiation therapy. The present proposal contributes to the elucidation of the mechanisms underlying bystander effects by evaluating intercellular communication as a determinant of the response, and DNA double strand breaks as initiating lesions. Using biological model systems with conditional induction of intercellular communication and diverse experimental approaches, some of which are developed and tested here, we aim to investigate the induction kinetics of by stander effects in cultured cells and evaluate their contribution to the response of tumors growing in nude mice to ionizing radiation. The results should allow the definition of targets for pharmacological intervention to protect humans from the adverse effects of ionizing radiation. Campo scientifico natural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencesnuclear physics Programma(i) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Argomento(i) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF ESSEN Contributo UE Nessun dato Indirizzo Hufelandstrasse 55 45147 ESSEN Germania Mostra sulla mappa Costo totale Nessun dato Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto BUNDESREPUBLIK DEUTSCHLAND Germania Contributo UE Nessun dato Indirizzo Budensallee 100 38116 BRAUNSCHWEIG Mostra sulla mappa Costo totale Nessun dato FACULTY OF MEDICINE/UNIVERSITY HOSPITAL GOETTINGEN Germania Contributo UE Nessun dato Indirizzo Robert-Koch-Strasse 40 37075 GOETTINGEN Mostra sulla mappa Costo totale Nessun dato NATIONAL CENTRE FOR SCIENTIFIC RESEARCH 'DEMOKRITOS' Grecia Contributo UE Nessun dato Indirizzo Terma Patriarchou Grigoriou 15310 ATHENS Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF ST ANDREWS Regno Unito Contributo UE Nessun dato Indirizzo Queen's Terrace Bute Medical Buildings KY16 9TS St Andrews, Fife Mostra sulla mappa Costo totale Nessun dato