The role of endoglin in the cellular responses to tgf-beta

Project Information

Grant agreement ID: FMBI950237

Project closed

Start date 1 February 1996

End date 31 January 1997

Funded under

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Total cost No data

EU contribution No data

Coordinated by

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Objective

Endoglin is a homodimeric membrane glycoprotein, highly expressed in endothelial cells and macrophages, and with capacity to bind transforming growth factor-Beta (TGF-Beta). Endoglin is a component of the membrane TGF-Beta receptor system, although its specific role in the TGF-Beta induced cellular responses is not known. To study the functional role, we will analyze the TGF-Beta responses of stable transfectants in human U-937 cells expressing two different endoglin isoforms (L-endoglin and S-endoglin) with distinct cytoplasmic tails. U-937 cells are responsive to TGF-Beta, as previously studied in our laboratory, and we will analyze the cellular proliferation, migration, aggregation, fibro- nectin synthesis, upregulation of membrane adhesion molecules, levels of c-myc, c-fos and c-jun mRNA, as well as the TGF-Beta binding capacity of the different membrane receptors.

Programme(s)

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Topic(s)

• 0302 - Post-doctoral research training grants
• TL05 - Cell Biology

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

• EU contribution: No data
• Address: 144,Velazquez 144 ; 28006 MADRID ; Spain
• Total cost: No data

Participants (1)

Not available

Germany

• EU contribution: No data
• Total cost: No data