Cel Endoglin is a homodimeric membrane glycoprotein, highly expressed in endothelial cells and macrophages, and with capacity to bind transforming growth factor-Beta (TGF-Beta). Endoglin is a component of the membrane TGF-Beta receptor system, although its specific role in the TGF-Beta induced cellular responses is not known. To study the functional role, we will analyze the TGF-Beta responses of stable transfectants in human U-937 cells expressing two different endoglin isoforms (L-endoglin and S-endoglin) with distinct cytoplasmic tails. U-937 cells are responsive to TGF-Beta, as previously studied in our laboratory, and we will analyze the cellular proliferation, migration, aggregation, fibro- nectin synthesis, upregulation of membrane adhesion molecules, levels of c-myc, c-fos and c-jun mRNA, as well as the TGF-Beta binding capacity of the different membrane receptors. Program(-y) FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998 Temat(-y) 0302 - Post-doctoral research training grants TL05 - Cell Biology Zaproszenie do składania wniosków Data not available System finansowania RGI - Research grants (individual fellowships) Koordynator CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Wkład UE Brak danych Adres 144,Velazquez 144 28006 MADRID Hiszpania Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko Not available Niemcy Wkład UE Brak danych Adres Zobacz na mapie Koszt całkowity Brak danych