Objective
The interphase nuclear envelope is a selective barrier which defines the boundary between the nucleus and cytoplasm and as such governs the transport of macromolecules between these two compartments. In this regard the nuclear envelope plays a central role in determining nuclear activity during cell growth and development. The channels which mediate this regulated traffic of molecules across the nuclear envelope are the nuclear pore complexes (NPCs). These are not simple pores embedded in the nuclear envelope but large and elaborated supra molecular assemblies. At present the nature of the molecular machinery within the pore complex and interactions with other nuclear and cytoplasmic components remain largely obscure.
We have characterized a group of nuclear complex proteins and begin to map their functional and physical interactions. It is the goal of this proposal to study in greater detail a novel component of the NPC that we have identified and cloned. This will provide new information on the organization and function of the NPC.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75251 PARIS
France
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