Skip to main content
Ir a la página de inicio de la Comisión Europea (se abrirá en una nueva ventana)
español es
CORDIS - Resultados de investigaciones de la UE
CORDIS
Contenido archivado el 2024-05-14

Structural and functional analysis of nup84, a novel nuclear pore complex protein associated with can/nup214

Objetivo



The interphase nuclear envelope is a selective barrier which defines the boundary between the nucleus and cytoplasm and as such governs the transport of macromolecules between these two compartments. In this regard the nuclear envelope plays a central role in determining nuclear activity during cell growth and development. The channels which mediate this regulated traffic of molecules across the nuclear envelope are the nuclear pore complexes (NPCs). These are not simple pores embedded in the nuclear envelope but large and elaborated supra molecular assemblies. At present the nature of the molecular machinery within the pore complex and interactions with other nuclear and cytoplasmic components remain largely obscure.
We have characterized a group of nuclear complex proteins and begin to map their functional and physical interactions. It is the goal of this proposal to study in greater detail a novel component of the NPC that we have identified and cloned. This will provide new information on the organization and function of the NPC.

Ámbito científico (EuroSciVoc)

Programa(s)

Tema(s)

Convocatoria de propuestas

Datos no disponibles

Régimen de financiación

RGI - Research grants (individual fellowships)

Coordinador

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Aportación de la UE
Sin datos
Dirección
2,Place Jussieu 2, Tour 43, 4ème étage
75251 PARIS
Francia
Coste total
Sin datos

Participantes (1)