Objectif
The aim of the proposal is to try and develop a new catalytic cycle for the asymmetric synthesis of aziridines from electron rich and deficient alkenes. Aziridines are important because the products are versatile synthetic intermediates in the synthesis of agrochemicals and pharmaceuticals and because of the growing demand to produce enantiomerically pure compounds. The key to our strategy involves designing novel catalytic processes which exploit the weak nature of N-heteroatom bonds and use metal salts as catalysts to control the process. As reactions will only occur on metal templates, correct juxtaposition of chiral ligands around the metal should allow the development of an enantioselective process. We also wish to exploit this chemistry in the synthesis of epibatidine - a compound with potential for treament of mental illnesses.
Champ scientifique (EuroSciVoc)
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.
- sciences médicales et de la santémédecine fondamentalepharmacologie et pharmacieproduit pharmaceutique
- sciences naturellessciences chimiquescatalyse
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Appel à propositions
Data not availableRégime de financement
RGI - Research grants (individual fellowships)Coordinateur
S3 7HF Sheffield
Royaume-Uni