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Development of a bioreactor-based connective tissue production line (TISSUE REACTOR)

Objectif

It is the aim of this project to engineer connective tissue in vitro and to demonstrate its applicability as a tissue substitute in vivo. To achieve this goal a continuous cultivation process based on a perfused fixed-bed bioreactor system and its components will be developed which allows the production of large quantities of three-dimensional (3-d) tissue cultures in combination with capillary-like prevascular precursors to form in vitro tissue constructs. The primary focus will be bone tissue, and bone tissue constructs will then subsequently be implanted in vivo to demonstrate their potential to improve current limitations in bone substitution surgery.

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

University of Ulm
Adresse
Albert-einstein-allee 11
89070 Ulm
Allemagne

Participants (8)

BIOSCAN B.V.
Pays-Bas
Adresse
10,Prof. Bronkhorstlaan 10 Bld.d
3723 MB Bilthoven
CAM IMPLANTS B.V.
Pays-Bas
Adresse
Zernikedreef 6
2333 CL Leiden
GBF - NATIONAL CENTRE FOR BIOTECHNOLOGY
Allemagne
Adresse
Mascheroder Weg 1
38124 Braunschweig
MEREDOS GMBH
Allemagne
Adresse
37,Alte Dorfstraat 37
37120 Bovenden
MNEMOSCIENCE GMBH
Allemagne
Adresse
Pauwelsstrasse 19
52074 Aachen
UNIVERSITY OF AVEIRO
Portugal
Adresse
Campo Universitario De Santiago
3810-193 Aveiro
UNIVERSITY OF MANCHESTER
United Kingdom
Adresse
Oxford Road
Manchester
UNIVERSITY OF NOTTINGHAM
United Kingdom
Adresse
University Park
NG7 2RD Nottingham