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Development of dedicated flow cells for 800 mhz and 600 mhz cryoprobes to measure small amounts of samples or samples of low concentrations

Objective

Description:

The three European Research Infrastructures for Biomolecular NMR and the European Leading Company in the manufactory of NMR spectrometers decided to synergize their efforts to improve the quality of access to their infrastructures. The aim of the present project is to develop flow cells that can be compatible with, and usable in, existing and future cryoprobes. It is intended to provide such flow cells with an active volume of 200 microliters for the existing 5 mm cryoprobesat 600 MHz and for prospective 800 MHz cryoprobe. The ultimate goal is the development of an ultra small flow cell designed to operate with 800 MHz cryoprobes with an active volume as small as 50 microliters.

The achievement of these major deliverables should open new application avenues with particular interest for the fields of:
a) screening methods;
b) characterization of natural products available in low quantities;
c) high sensitivity method to monitor purification steps of biological samples;
d) hyphenated methods in combinatorial chemisty. This is expected to improve not only the quality but also the quantity of access; indeed new potential users of the Facilities will be attracted by the applications of this project deliverables.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLOPROTEINE PARAMAGNETICHE
Address
Via L. Sacconi 6 C/o Università Di Firenze
50019 Firenze
Italy

Participants (2)

JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT
Germany
Address
7,Marie-curie-strasse 9
60439 Frankfurt Am-main
UTRECHT UNIVERSITY
Netherlands
Address
8,Padualaan 8
3584 CH Utrecht