Objective
* To consolidate work of the already established vaccine evaluation centre in the Philippines, i.e. the Research Institute for Tropical Medicine (RITM), Manila and to develop a new vaccine evaluation center in Vietnam as collaboration between the Pediatric Hospital No 1 (PHN1) and its counterpart (RH), Copenhagen.
* To obtain baseline epidemiologic information from the two centres on natural acquisition of pneumococcal (Pnc) and Haemophilus influenzae type b (Hib) antibodies and of Pnc and Hib in the etiology of ARI in children <5 years of age.
* To monitor the safety and determine the immunogenicity of candidate vaccines (Pnc and Hib conjugate vaccines) in infants in the SEA region.
Expected Outcome
* There will be two experienced vaccine evaluation centers in South-East Asia.
* Safety and immunogenicity of pneumococcal conjugate vaccine established.
* Safety and immunogenicity of Hib conjugate vaccine established in Vietnam.
* Basal data needed for the planning of Pnc and Hib vaccination programs and efficacy trial will be available from two areas in the South-East Asian region.
* Collect baseline antibody and carriage data of Pnc and Hib in the Philippines and Vietnam.
* Determine the role and types of Pnc and Hib in hospital treated pneumonia in children less than 5 years of age (Philippines, Vietnam).
* Vaccination by public health personnel in local health centers within EPI schedule. Vaccine safety measured by structured parental monitoring and home visits by a nurse.
* A venous blood sample is obtained when the child enters the study at specified time points after vaccination. All antibody analyses will be done at KTL.
* Safety and immunogenicity of the Hib conjugate in infancy in Vietnam will be studied as above. The data will also provide baseline information referred to above.
* Monitoring of the quality of the research, cold chain, laboratory, forms, and data entry will be carried out according to GLP/GCP principles.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences tropical medicine
- medical and health sciences clinical medicine pneumology
- medical and health sciences health sciences public health
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Coordinator
00300 Helsinki
Finland
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