Objective
* To continue and complete ongoing immuno-epidemiological research on the role and development of age-related acquired resistance to (re-)infection with schistosoma mansoni in recently established foci in Northern Senegal.
* To investigate the consistently observed poor therapeutic responses to praziquantel in this focus, with particular respect to the possibility of reduced parasite susceptibility and to the interference of underdeveloped immune responses.
* To further investigate the ecological dynamics of this unstable epidemic situation, with particular respect to the spread and vectorial capacity of the intermediate host.
* To develop, evaluate and implement sustainable intervention strategies, focussing on passive case detection and safe water supply; health information systems within the existing health services.
* To follow-up and further document the clinical pathology, community morbidity and public health impact of S.mansoni infection in this epidemic focus in its transition to endemicity.
* To further strengthen the research and intervention capacity of the Senegalese team by providing training up to Msc/PhD level in each of the above fields, and to consolidate the established collaborative and network links.
* In-depth analysis and exploitation of data and samples collected in the previous STD3-project (immunology, epidemiology, diagnostics, chemotherapy).
* Further, well oriented studies in immuno-epidemiology, chemotherapy, morbidity, in newly established foci in the area.
* Documentation in the laboratory and in the field the vectorial capacity of the intermediate host, and the possible ecological and genetic determining factors.
* Breeding a number of isolates of the local S.mansoni strain and to test in vivo, possibly in vitro, their susceptibility to praziquantel and oxamniquine, and to study possible biochemical and genetic markers of resistance.
* Clinical and community-based studies in order to optimise clinical definition and classification of specific intestinal and hepatoplenic disease and morbidity.
* Translation of these findings in optimal decision trees for case-management and disease surveillance at primary, secondary and tertiary health services.
* Masters- and PhD-training to Senegalese researchers and health workers active in this project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health epidemiology
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pathology
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Coordinator
2000 ANVERS /ANTWERPEN
Belgium
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