Objective
General objective
To analyse the impact of specific genetic subtypes on the natural history of HIV-1 infection.
Specific objective
* To identify the genetic subtype circulating in three existing cohorts of HIV infected patients in Senegal, Cameroon and Guinea-Bissau; to study virological and antigenic characteristics related to the genotype.
* To identify risk factors associated to specific genotypes and to assess clinical, immunological and virological parameters as well as survival over 3 years period in HIV-1 infected patients according to genotypes.
Expected Outcome
The potential benefits of the proposed projects are multiple. A better clinical care of HIV infected patients is offered through a standardized approach and with the possibility to treat infections due to the immuno-depression.
This project consists on two parts:
First, a transversal study among ongoing cohorts of HIV infected patients in Senegal, Cameroon and Guinea-Bissau will allow to determine the prevalence of the different genotypes circulating in this populations and to characterize their virological properties. Both heteroduplex mobility assay (HMA) and V3 peptide serology will be used to diagnose the different genetic groups and subtypes of HIV-1. An algorithm will be developed to simplify the genetic subtyping of HIV-1. The biological phenotype will be analyzed and correlated with the genetic sequence of the V3 loop. Risk factors associated to genotypes will be analyzed.
Secondly, the possibility to perform a follow-up of HIV-infected patients in Senegal, Guinea-Bissau and Cameroon allows us to initiate a prospective study in order to assess clinical, immunological and virological parameters as well as survivial over a three year period. The biological phenotype will be determined every 6 months and correlated with CD4 counts and clinical parameters. Several clinical, serological, virological and immunological parameters will be studied in order to see if certain genotypes have a different pathogenesis and prognosis for HIV disease development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- humanities history and archaeology history
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences health sciences infectious diseases RNA viruses HIV
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
34032 Montpellier
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.