Objectif Malaria vaccines are urgently required. Recombinant multi-component cocktail vaccines are currently favoured. Using very recent technological advances this programme revives the concept of attenuated parasites as vaccines. It bring together for the first leading EU and African groups to develop methodologies allowing the design and creation of parasites with properties desirable in such a vaccine. The ultimate delivery of such a vaccine may be as either sexually incompetent, genetically restricted parasites, or as transmissible self-spreading forms. For either route certain fundamental pre-conditions must be met, and these are the major focus of this proposal; Systems will be developed to provide1) auxotrophic parasites2) sequential unrestricted genetic manipulation of parasites3) axenic culture4) parasite knock outs for specific genes and5) immuno-potentiated parasites through heterologous gene expression. In combination with a dialogue across scientific and public interests this programme will enable the partnership to provide a clear assessment of the feasibility of vaccination with genetically modified malaria within three years. Champ scientifique sciences médicales et de la santésciences de la santémaladie infectieusepaludismesciences médicales et de la santébiotechnologie médicalegénie génétiquesciences médicales et de la santémédecine fondamentalepharmacologie et pharmacieproduit pharmaceutiquevaccins Programme(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Thème(s) Data not available Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur LEIDEN UNIVERSITY Adresse Wassenaarseweg 72 2333 AL Leiden Pays-Bas Voir sur la carte Contribution de l’UE € 0,00 Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE Pays-Bas Contribution de l’UE € 0,00 Adresse 151,lange kleiweg 151 2280 GH Rijswijk zh Voir sur la carte MED BIOTECH LABORATORIES Ouganda Contribution de l’UE € 0,00 Adresse Sekindi close plot 3438 - myenga 10 Kampala Voir sur la carte UNIVERSITAETSKLINIKUM HEIDELBERG Allemagne Contribution de l’UE € 0,00 Adresse Im neuenheimer feld 324 69120 Heidelberg Voir sur la carte UNIVERSITY COLLEGE OF IBADAN Nigeria Contribution de l’UE € 0,00 Adresse University college hospital Ibadan Voir sur la carte
