Objective
Our remain rationale is that surface receptor-based research could have clinical application to control infectious diseases. The aim is to provide new target molecules for better diagnosis, vaccine and prophylaxis. The disease of interest is amoebiasis caused by Entamoeba histolytica, a parasite that represents a major public health problem in Latin America. Pathogenesis involves colonization and invasion of the human intestine and requires the activity of amoebic receptors like the Eh112 complex involved in phagocytosis of cells. We aim to provide targets for therapy and give rational alternatives for control of amoebiasis by a multidisciplinary approach extending from cell and molecular biology to immunology and epidemiological analysis. Key aspect are: parasite targets on human cells, phagocytosis by activation of the cytoskeleton, seroprevalence of Eh112 in endemic areas and assessment of the immune response.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health scienceshealth sciencespublic health
- medical and health scienceshealth sciencesinfectious diseases
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- natural sciencesbiological sciencesmolecular biology
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Topic(s)
Data not availableCall for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
75724 PARIS
France