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Contenido archivado el 2024-06-18

Development of new strategies for treatment of amoebiasis, the parasitic disease caused by entamoeba histolytica

Objetivo

Our remain rationale is that surface receptor-based research could have clinical application to control infectious diseases. The aim is to provide new target molecules for better diagnosis, vaccine and prophylaxis. The disease of interest is amoebiasis caused by Entamoeba histolytica, a parasite that represents a major public health problem in Latin America. Pathogenesis involves colonization and invasion of the human intestine and requires the activity of amoebic receptors like the Eh112 complex involved in phagocytosis of cells. We aim to provide targets for therapy and give rational alternatives for control of amoebiasis by a multidisciplinary approach extending from cell and molecular biology to immunology and epidemiological analysis. Key aspect are: parasite targets on human cells, phagocytosis by activation of the cytoskeleton, seroprevalence of Eh112 in endemic areas and assessment of the immune response.

Ámbito científico (EuroSciVoc)

CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.

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Tema(s)

Data not available

Convocatoria de propuestas

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Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

INSTITUT PASTEUR
Aportación de la UE
Sin datos
Dirección
Rue du Docteur Roux 25
75724 PARIS
Francia

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Coste total
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Participantes (4)