Objective
The Russian group will synthesize protein molecules, their substrates and ligands and analogues. The proteins under study will be purified and characterised biochemically and spectroscopically. Experiments to crystallise proteins, in the free state and complexed with substrates and ligands and their analogues, will be undertaken.
The Choubnikov group will study the interpretation of electron density maps of protein molecules. There will be an investigation of methods to characterise electron density maps with desirable and undesirable characteristics and non-negative density and contrast.
The interpretation of the active sites of the protein structureand their chemistry will also be carried out and will be used to design new substrate analogues and inhibitors. This will be particularly important in the ribonuclease studies where the complex interactions between the enzyme and distend ribonucleotides that govern specificity will be investigated.
The York group will carry out the crystal structure analysis of the proteins. This will begin with crystallisation experiments. The X-ray diffraction data will be collected and processed using both rotating anode and synchrotron radiation sources. The structures will be solved by molecular replacement methods, though anomalous scattering and other effects may also be exploited. Once solved the molecules and the associated water will be visualised, refined and analysed. Inspection of the protein and its substrate contacts will be carried out on high performance graphics.
The application of the direct methods will also be carried out by the York group. These calculations will produce a series of possible solutions which will be interpreted by inspection on the graphics devices and also by reference to figures of merit criteria.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
YO1 5DD YORK
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.