Objective
Lymphokine-activated killer (LAK) cells have high anti-tumour activity against autologous and allogenic tumour cells. This cell mediated cytotoxicity is due both to secreted and to membrane-associated cytotoxic proteins. The tumour necrosis factor, lymphotoxin and gamma-interferon, contribute to the cytotoxicity of LAK cells but other cytotoxic factors from LAK cells have not been characterised.
The cytotoxic proteins from LAK cells will be purified in order to determine their partial amino acid sequence and then to clone their genes. Primary structure, immunoreactivity and biological activity of the purified proteins (induction of necrotic or apoptotic pathways of target cells death, specificity to different target cells, etc.) will be compared with the tumour necrosis factor. The results obtained will be valuable for use in continuing research to elucidate the molecular mechanism of anti-tumour activity of cytotoxic lymphocytes and may find applicability in the development of treatment of tumour diseases.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
34012 Trieste
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.