European collaboration on craniofacial anomalies

Objetivo

This proposal is designed to improve the management and understanding of craniofacial anomalies (CFA). Integration of previous networks established to investigate clinical care (Eurocleft.) and gene-environment interaction in early human development (ESF network) provides, for the first time in Europe, adequate clinical resources and multidisciplinary critical mass. The work includes:
1) a multicentre randomised control trial of surgery for orofacial clefting (OFC);
2) a multicentre population based case-parental triad study of the role of specific genes, gene-environment interaction and gene-gene interaction in the aetiology of OFC;
3) a chromosomal approach to the identification of candidate genes for OFC;
4) development of sensitive molecular diagnostic assay for mutations underlying monogenic CFA; and
5) an informatics resource to underpin the other work and provide a dynamic resource to disseminate findings, assist CFA researchers, and promote good practice in clinical services. The project will be integrated with, and provide leadership for, a proposed global effort in the treatment and prevention of CFA.

Ámbito científico

• ciencias médicas y de la salud › medicina clínica › cirugía
• ciencias naturales › ciencias biológicas › genética › mutación

Programa(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Tema(s)

• 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

UNIVERSITY OF MANCHESTER

Dirección

Higher Cambridge Street
M15 6FH Manchester
United Kingdom

Participantes (18)

AZIENDA OSPEDIALIERA SAN PAOLO, MILANO

Italia

Dirección

Via Antonio Di Rudini N°8
20142 Milano

CLEFT PALATE FOUNDATION

Hungría

Dirección

Huevoesvoelgyi Ut, 35
1026 Budapest

COMENIUS UNIVERSITY

Eslovaquia

Dirección

Sasinovska, 4
81108 Bratislava

GOETEBORG UNIVERSITY

Suecia

Dirección

Sahlgrenska Sjukhuset
413 45 Goeteborg

MEDICAL INSTITUTE OF PLOVDIV

Bulgaria

Dirección

Boulevard Peschtersko Chaussee,66
4002 Plovdiv

NORTH ESTONIAN REGIONAL HOSPITAL

Estonia

Dirección

Suetiste Tee 19
13419 Tallinn

OSAKJDETZA SERVICIO VASCO DE SALUD

España

Dirección

Plaza De Cruces 12
489031 Barakaldo-vizcaya

SPEECH AND HEARING INSTITUTE, HELLERUP

Dinamarca

Dirección

Rygards Allee 45
2900 Hellerup

STICHTING KATHOLIEKE UNIVERSITEIT

Países Bajos

Dirección

Philips Van Leijdenlaan 25
6500 HB Nijmegen

Enlaces

THE NATIONAL HOSPITAL UNIVERSITY OF OSLO

Noruega

Dirección

Sognsvannsvn. 20
0027 Oslo

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN

Irlanda

Dirección

College Green
4 Dublin

UNIVERSITA DEGLI STUDI DI FERRARA

Italia

Dirección

Via Luigi Borsari, 46
44100 Ferrara

UNIVERSITY MEDICAL CENTER LJUBLJANA

Eslovenia

Dirección

Slajmerjeva, 3
1000 Ljubljana

UNIVERSITY OF ABERDEEN

United Kingdom

Dirección

Polwarth Building, Foresterhill
AB25 2ZD Aberdeen

UNIVERSITY OF COPENHAGEN

Dinamarca

Dirección

Noerregade 10
1017 Koebenhavn K/copenhaegen

UNIVERSITY OF DUNDEE

United Kingdom

Dirección

Park Place
DD1 4HR Dundee

UNIVERSITY OF HELSINKI

Finlandia

Dirección

Yliopistonkatu 4
00014 Helsinki

University of Edinburgh

United Kingdom

Dirección

Old College South Bridge
EH1 1HN Edinburgh