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The role of tissue transglutaminase in inducing gluten t cell response and autoantibody formation in coeliac disease

Objective

Deamidation and transamidation activities of tTG are measured and the influence of tTG autoantibodies is determined. Gluten-tTG complexes are applied to investigate the role of cognate T/B cell interaction for the formation of tTG autoantibodies. An in vitro marine system, a marine adoptive transfer model and an in vitro human system will be used.

Funding Scheme

RGI - Research grants (individual fellowships)
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Coordinator

THE NATIONAL HOSPITAL UNIVERSITY OF OSLO
Address
Pilestredet 32
0027 Oslo
Norway