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The leukotrienes, signalling molecules in chronic and degenerative diseases

Objective

The leukotrienes (LT) are important lipid signalling molecules in chronic inflammatory disorders affecting, e.g., the joints and respiratory system, which are serious health problems with a major socio-economic impact. Our network, positioned in the international forefront of LT research, will carry out a multidisciplinary project with the aims to elucidate the underlying LT-dependent disease mechanisms and contribute to the development of novel therapeutic strategies and anti-LT drugs. The work will focus on molecular studies of key enzymes and receptors, regulation of cellular LT synthesis, the role of LTs in the immune system and characterisation of new potential drug targets, in combination with applied studies in complex models of inflammatory diseases. Our project will be conducted in alliance with the industry and has the potential for future extension into medical practice and treatment of chronic and degenerative diseases.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

KAROLINSKA INSTITUTE
Address
9,Doktorsringen 9 A
171 77 Stockholm
Sweden

Participants (2)

JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT
Germany
Address
9,Marie-curie-strasse 9
60439 Frankfurt Am-main
THE UNIVERSITY OF MILANO
Italy
Address
Via Balzaretti 9
20133 Milano