Objective The project is aimed at a comprehensive analysis of the pathophysiology of a group of rare, but severe and chronic autoimmune bullous skin disorders, the pemphigoids (PEs), characterized by defective epithelial adhesion and autoantibodies against components of the skin basement membrane zone. These diseases represent a prototype of organ-specific autoimmune disorders which share common pathogenetic mechanisms. The objectives are: the analysis of molecular interactions and processing of epithelial adhesion proteins targets in the PEs; the characterization of the humoral immune responses and T cell immune responses in the PEs; the study of disease development risk factors. Expected results are: (i) a better understanding of the immunopathogenesis of PEs disorders; (ii) the definition of markers for disease severity, progression and outcome, (iii) the identification of subjects at risk for disease, (iv) the development of new diagnostic tools and of (v) novel immunotherapy for these diseases. Altogether these results will also enhance understanding and allow development of new diagnostic and therapeutic approaches in other autoimmune disorders. Fields of science medical and health sciencesbasic medicinephysiologypathophysiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologyimmunotherapy Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator PROVINCIA ITALIANA DELLA CONGREGAZIONE DEI FIGLI DELL'IMMACOLATA CONCEZIONE - ISTITUTO DERMOPATICO DELL'IMMACOLATA Address Via dei monti di creta 104 00167 Roma Italy See on map EU contribution € 0,00 Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 0,00 Address Avenue de valombrose 28 06107 Nice See on map UNIVERSITAETSKLINIKUM FREIBURG Germany EU contribution € 0,00 Address Hauptstrasse 7 79104 Freiburg (in breisgau) See on map UNIVERSITY OF ERLANGEN-NUREMBERG Germany EU contribution € 0,00 Address 14,hartmannstrasse 14 91052 Erlangen See on map WIESLAB AB Sweden EU contribution € 0,00 Address Ideon research park 223 70 Lund See on map
